Evidence map›Paper›PMID 29490631›Full record

ArticleBMC pediatrics2018

Medullary unidentified bright objects in Neurofibromatosis type 1: a case series.

Alessandra D'Amico, Federica Mazio, Lorenzo Ugga, Renato Cuocolo, Mario Cirillo, Claudia Santoro, Silverio Perrotta, Daniela Melis, Arturo Brunetti

Abstract readCase Reports
In one paragraph

Article in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Clinical report of a brain magnetic resonance imaging finding in Noonan syndrome.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Article
  3. Review
  4. Olfactory bulb enlargement in neurofibromatosis type 1: report of a novel finding.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Article
  5. Review
  6. Multimodal evaluation of the cerebrovascular reserve in Neurofibromatosis type 1 patients with Moyamoya syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Observational
  7. Neurological manifestations of neurofibromatosis: a review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020
    Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessandra D'AmicoDepartment of Advanced Biomedical Sciences, "Federico II" University, via Sergio Pansini 5, 80100, Naples, Italy.
Federica MazioDepartment of Advanced Biomedical Sciences, "Federico II" University, via Sergio Pansini 5, 80100, Naples, Italy.
Lorenzo UggaDepartment of Advanced Biomedical Sciences, "Federico II" University, via Sergio Pansini 5, 80100, Naples, Italy.
Renato CuocoloDepartment of Advanced Biomedical Sciences, "Federico II" University, via Sergio Pansini 5, 80100, Naples, Italy. renato.cuocolo@gmail.com.ORCID 0000-0002-1452-1574
Mario CirilloDepartment of Medical, Surgical, Neurological, Metabolic and Aging Sciences, "Seconda Università degli Studi di Napoli" University, via Costantinopoli 104, 80100, Naples, Italy.
Claudia SantoroRegional Referral Center for Neurofibromatosis, Department of Woman, Child, General and Specialistic Surgery, "Seconda Università degli Studi di Napoli" University, via Costantinopoli 104, 80100, Naples, Italy.
Silverio PerrottaRegional Referral Center for Neurofibromatosis, Department of Woman, Child, General and Specialistic Surgery, "Seconda Università degli Studi di Napoli" University, via Costantinopoli 104, 80100, Naples, Italy.
Daniela MelisDepartment of Translational Medical Sciences, "Federico II" University, via Sergio Pansini 5, 80100, Naples, Italy.
Arturo BrunettiDepartment of Advanced Biomedical Sciences, "Federico II" University, via Sergio Pansini 5, 80100, Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn Neurofibromatosis type 1, cerebral Unidentified Bright Objects are a well-known benign entity that has been extensively reported in the literature. In our case series, we wish to focus on a further possible location of such lesions, the spinal cord, which we have defined as medullary Unidentified Bright Objects. These have been, to our knowledge, scarcely described in previous works. CASE PRESENTATION: We report the cases of 7 patients with medullary Unidentified Bright Objects in Neurofibromatosis type 1 that we have followed for up to 9 years in our Regional Referral Center for Neurofibromatosis. In all of our patients, these lesions were completely asymptomatic and reported on Magnetic Resonance exams the patients underwent for other clinical indications.

conclusionsThe aim of our work is to increase awareness of the possibility of medullary Unidentified Bright Objects in Neurofibromatosis type 1 patients, which can simulate neoplastic lesions, suggesting a more conservative approach in these cases.

Indexed as

Magnetic Resonance ImagingAdolescentAdultCervical VertebraeChildDiagnosis, DifferentialFemaleFollow-Up StudiesHumansIncidental FindingsMaleNeurofibromatosis 1Spinal CordThoracic VertebraeMagnetic resonance imagingNeurofibromatosis ISpineT2-hyperintense lesionsUnidentified bright objects

Identifiers

PMID29490631
PMCPMC5832195

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.