ArticleGrowth factors (Chur, Switzerland)2017
Toll-like receptor 4 regulates insulin signal transduction in retinal Müller cells.
Article in Growth factors (Chur, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Toll-Like Receptor Signalling Pathways and the Pathogenesis of Retinal Diseases.Frontiers in ophthalmology · 2022Review
- Loss of TLR4 in endothelial cells but not Müller cells protects the diabetic retina.Experimental eye research · 2021Article
- Insulin Signal Transduction is Impaired in the Type 2 Diabetic Retina.Journal of diabetes and clinical research · 2020Article
- Beneficial effects ofClinical and experimental gastroenterology · 2019Review
- HMGB1 inhibits insulin signalling through TLR4 and RAGE in human retinal endothelial cells.Growth factors (Chur, Switzerland) · 2018Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Dysfunctional insulin signalling is a causative factor in type-2 diabetes. While insulin signal transduction has been well investigated in many tissues, less is known in retinal tissues. We have previously reported that toll-like receptor 4 (TLR4) is involved in retinal damage in diabetes. We used TLR4 retinal Müller cell-specific knockout mice and Müller cells in culture to investigate the effects of loss of TLR4 on Müller cell insulin signal transduction. Loss of TLR4 in the mouse retinal Müller cells led to increased insulin receptor and Akt phosphorylation, with reduced insulin receptor substrate 1 (IRS-1) phosphorylation on serine 307, which was associated with reduced cleavage of caspase 3. In retinal Müller cells grown in high glucose, insulin signal transduction was impaired, but these responses were reduced with cells were transfected with TLR4 siRNA. Taken together, the data suggest that TLR4 regulates insulin signal transduction in retinal Müller cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.