Evidence map›Paper›PMID 29490477›Full record

ReviewAntioxidants & redox signaling2019

Hypertrophic Cardiomyopathy: A Vicious Cycle Triggered by Sarcomere Mutations and Secondary Disease Hits.

Paul J M Wijnker, Vasco Sequeira, Diederik W D Kuster, Jolanda van der Velden

Open access · greenAbstract readReview
In one paragraph

Review in Antioxidants & redox signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Immature and mature myocardium in the pathophysiology of hypertrophic cardiomyopathy.Journal of molecular and cellular cardiology plus · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Missense variants in the myosin binding domains ofbioRxiv : the preprint server for biology · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Paul J M Wijnker1 Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, The Netherlands.
Vasco Sequeira1 Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, The Netherlands.
Diederik W D Kuster1 Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, The Netherlands.
Jolanda van der Velden1 Department of Physiology, Amsterdam Cardiovascular Sciences, VU University Medical Center, Amsterdam, The Netherlands.
Netherlands Heart Institute · NL

Funding

MOLECULAR PHYSIOLOGY OF MYOCARDIAL TROPONIN I VARIANTSR01HL063038 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MURPHY, ANNE M · 1999 to 2018
$6.2M
NHLBI NIH HHS R01 HL063038
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MutationAllelesAnimalsCalciumCardiomyopathy, HypertrophicEpigenesis, GeneticHumansReactive Oxygen SpeciesSarcomeresCalciumReactive Oxygen Specieshypertrophic cardiomyopathymitochondrionpathophysiological mechanismreactive oxygen speciesredox statesarcomeric gene mutation

Identifiers

PMID29490477
PMCPMC6602117
OpenAlexW2884468910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.