ArticleCell reports2018
P2RY1/ALK3-Expressing Cells within the Adult Human Exocrine Pancreas Are BMP-7 Expandable and Exhibit Progenitor-like Characteristics.
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Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
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32 citing papers in PubMed, 64 citations in OpenAlex.
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- Mechanisms inducing differentiation of adult islet progenitor-like cells into functional islet-like organoids.Frontiers in transplantation · 2026Article
- Benchmarking porcine pancreatic ductal organoids for drug screening applications.EMBO molecular medicine · 2025Article
- Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123.Nature communications · 2025Article
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- Cycling alpha cells in regenerative drug-treated human pancreatic islets may serve as key beta cell progenitors.Cell reports. Medicine · 2024Article
- Biotechnology Revolution Shaping the Future of Diabetes Management.Biomolecules · 2024Review
- Engineered tools to study endocrine dysfunction of pancreas.Biophysics reviews · 2024Review
- Acinar to β-like cell conversion through inhibition of focal adhesion kinase.Nature communications · 2024Article
- Rare, Tightly-Bound, Multi-Cellular Clusters in the Pancreatic Ducts of Adult Mice Function Like Progenitor Cells and Survive and Proliferate After Acinar Cell Injury.Stem cells (Dayton, Ohio) · 2024Article
- Activation of ductal progenitor-like cells from adult human pancreas requires extracellular matrix protein signaling.iScience · 2024Article
- The Values and Perspectives of Organoids in the Field of Metabolic Syndrome.International journal of molecular sciences · 2023Review
- Methylcellulose colony assay and single-cell micro-manipulation reveal progenitor-like cells in adult human pancreatic ducts.Stem cell reports · 2023Article
- Transcriptomic Deconvolution of Neuroendocrine Neoplasms Predicts Clinically Relevant Characteristics.Cancers · 2023Article
- Bone morphogenetic protein-7 attenuates pancreatic damage under diabetic conditions and prevents progression to diabetic nephropathy via inhibition of ferroptosis.Frontiers in endocrinology · 2023Article
- Type 1 diabetes and engineering enhanced islet transplantation.Advanced drug delivery reviews · 2022Review
- Islet organoid as a promising model for diabetes.Protein & cell · 2022Review
- Nuclear GSK-3β and Oncogenic KRas Lead to the Retention of Pancreatic Ductal Progenitor Cells Phenotypically Similar to Those Seen in IPMN.Frontiers in cell and developmental biology · 2022Article
- Purinergic and Adenosinergic Signaling in Pancreatobiliary Diseases.Frontiers in physiology · 2022Review
- Islet Regeneration and Pancreatic Duct Glands in Human and Experimental Diabetes.Frontiers in cell and developmental biology · 2022Article
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Authors and funding
12 authors at 2 institutions in 2 countries.
Mirza Muhammad Fahd QadirDiabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Cell Biology and Anatomy, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Silvia Álvarez-CubelaDiabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Dagmar KleinDiabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Giacomo LanzoniDiabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Carlos García-SantanaOphysio, Inc., Miami, FL, USA.
Abelardo MontalvoDiabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Fabiola Pláceres-UrayDiabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Emilia Maria Cristina MazzaIstituto Clinico Humanitas IRCCS, Milano 20089, Italy.
Camillo RicordiDiabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Microbiology & Immunology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Biomedical Engineering, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Luca Alessandro InverardiDiabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Microbiology & Immunology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Medicine, Division of Metabolism, Endocrinology and Diabetes, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Ricardo Luis PastoriDiabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Microbiology & Immunology, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Medicine, Division of Metabolism, Endocrinology and Diabetes, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Electronic address: rpastori@med.miami.edu.
Juan Domínguez-BendalaDiabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Cell Biology and Anatomy, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Electronic address: jdominguez2@med.miami.edu.
University of Miami · USIRCCS Humanitas Research Hospital · IT
Funding
technologyIn vitro maturation of BMP-7-responsive pancraeatic beta cell progenitors by oxygen modulation R44DK105655 · NIDDK · OPHYSIO, INC. · PI DOMINGUEZ-BENDALA, JUAN, LATTA, PAUL · 2016 to 2017
$1.4MIn vitro maturation of BMP-7-responsive pancreatic beta cell progenitors by oxygen modulation technologyR43DK105655 · NIDDK · OPHYSIO, INC. · PI DOMINGUEZ-BENDALA, JUAN, LATTA, PAUL · 2015 to 2015
$225kNIDDK NIH HHS R43 DK105655NIDDK NIH HHS R44 DK105655
Abstract
Treatment of human pancreatic non-endocrine tissue with Bone Morphogenetic Protein 7 (BMP-7) leads to the formation of glucose-responsive β-like cells. Here, we show that BMP-7 acts on extrainsular cells expressing PDX1 and the BMP receptor activin-like kinase 3 (ALK3/BMPR1A). In vitro lineage tracing indicates that ALK3
Indexed as
AdultBone Morphogenetic Protein 7Bone Morphogenetic Protein Receptors, Type ICell DifferentiationCell LineageCell ProliferationCells, CulturedDNA ReplicationHomeodomain ProteinsHumansPancreas, ExocrineStem CellsTrans-ActivatorsBone Morphogenetic Protein 7Bone Morphogenetic Protein Receptors, Type IHomeodomain Proteinspancreatic and duodenal homeobox 1 proteinTrans-ActivatorsALK3beta cell regenerationhuman pancreatic progenitor cellsislet regenerationPDX1
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