ArticleCell reports2018
Aspirin Recapitulates Features of Caloric Restriction.
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Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67citing papers in PubMed
12.3field-weighted citation impact, top 1% of its field
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Who cites it
67 citing papers in PubMed, 106 citations in OpenAlex.
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- Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.The EMBO journal · 2022Article
- Mitochondrial Dysfunction and Cardiovascular Disease: Pathophysiology and Emerging Therapies.Oxidative medicine and cellular longevity · 2022Review
- FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway.Autophagy · 2021Article
- A collective analysis of lifespan-extending compounds in diverse model organisms, and of species whose lifespan can be extended the most by the application of compounds.Biogerontology · 2021Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
21 authors at 14 institutions in 8 countries.
Federico PietrocolaGustave Roussy Cancer Campus, Villejuif, France; INSERM, U1138, Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Université Pierre et Marie Curie, Paris, France.
Francesca CastoldiGustave Roussy Cancer Campus, Villejuif, France; INSERM, U1138, Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Université Pierre et Marie Curie, Paris, France; Université Paris-Sud/Paris XI, Faculté de Médecine, Kremlin-Bicêtre, France, Paris, France; Sotio a.c., Prague, Czech Republic.
Maria MarkakiInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 70013, Crete, Greece.
Sylvie LachkarGustave Roussy Cancer Campus, Villejuif, France; INSERM, U1138, Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Université Pierre et Marie Curie, Paris, France.
Guo ChenGustave Roussy Cancer Campus, Villejuif, France; INSERM, U1138, Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Université Pierre et Marie Curie, Paris, France.
David P EnotMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France.
Sylvere DurandMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France.
Noelie BossutMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France.
Mingming TongDepartment of Cell Biology and Molecular Medicine, Rutgers-New Jersey Medical School, Newark, NJ, USA.
Shoaib A MalikGustave Roussy Cancer Campus, Villejuif, France; INSERM, U1138, Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Université Pierre et Marie Curie, Paris, France; Department of Biochemistry, Sargodha Medical College, Sargodha, Pakistan.
Friedemann LoosGustave Roussy Cancer Campus, Villejuif, France; INSERM, U1138, Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Université Pierre et Marie Curie, Paris, France.
Nicolas DupontUniversité Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Institut Necker-Enfants Malades (INEM), Paris, France; INSERM, U1151, Paris, France; CNRS, UMR8253, Paris, France.
Guillermo MariñoDepartamento de Biología Fundamental, Universidad de Oviedo, Fundación para la Investigación Sanitaria del Principado de Asturias (FINBA), Oviedo, Spain; Instituto de Investigación Sanitaria del Principado de Asturias (IISPA), Oviedo, Spain.
Nejma AbdelkaderScientific Computing, LGCR, Sanofi R&D, 94403 Vitry-sur-Seine, France.
Frank MadeoInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Humboldtstraße 50, 8010 Graz, Austria; BioTechMed-Graz, Humboldtstraße 50, 8010 Graz, Austria.
Maria Chiara MaiuriGustave Roussy Cancer Campus, Villejuif, France; INSERM, U1138, Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Université Pierre et Marie Curie, Paris, France.
Romano KroemerStructure Design & Informatics, LGCR, Sanofi R&D, 94403 Vitry-sur-Seine, France.
Patrice CodognoUniversité Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Institut Necker-Enfants Malades (INEM), Paris, France; INSERM, U1151, Paris, France; CNRS, UMR8253, Paris, France.
Junichi SadoshimaDepartment of Cell Biology and Molecular Medicine, Rutgers-New Jersey Medical School, Newark, NJ, USA.
Nektarios TavernarakisInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 70013, Crete, Greece; Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion 70013, Crete, Greece.
Guido KroemerGustave Roussy Cancer Campus, Villejuif, France; INSERM, U1138, Paris, France; Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; Université Paris Descartes/Paris V, Sorbonne Paris Cité, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Université Pierre et Marie Curie, Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden. Electronic address: kroemer@orange.fr.
Institut Gustave Roussy · FRRutgers New Jersey Medical SchoolSanofi (France) · FRSorbonne Université · FRUniversité Paris Cité · FRFoundation for Research and Technology Hellas · GRInserm · FRInstitut Necker Enfants Malades · FRInstituto de Investigación Sanitaria del Principado de Asturias · ESKarolinska University Hospital · SESorbonne Paris Cité · FRUniversité Paris-Saclay · FRUniversity of Crete · GRUniversity of Graz · AT
Funding
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5MNIH HHS P40 OD010440
Abstract
The age-associated deterioration in cellular and organismal functions associates with dysregulation of nutrient-sensing pathways and disabled autophagy. The reactivation of autophagic flux may prevent or ameliorate age-related metabolic dysfunctions. Non-toxic compounds endowed with the capacity to reduce the overall levels of protein acetylation and to induce autophagy have been categorized as caloric restriction mimetics (CRMs). Here, we show that aspirin or its active metabolite salicylate induce autophagy by virtue of their capacity to inhibit the acetyltransferase activity of EP300. While salicylate readily stimulates autophagic flux in control cells, it fails to further increase autophagy levels in EP300-deficient cells, as well as in cells in which endogenous EP300 has been replaced by salicylate-resistant EP300 mutants. Accordingly, the pro-autophagic activity of aspirin and salicylate on the nematode Caenorhabditis elegans is lost when the expression of the EP300 ortholog cpb-1 is reduced. Altogether, these findings identify aspirin as an evolutionary conserved CRM.
Indexed as
Caloric RestrictionAcetyl Coenzyme AAnimalsAspirinAutophagyCell Line, TumorE1A-Associated p300 ProteinHumansMetabolomeMetabolomicsMice, Inbred C57BLAcetyl Coenzyme AAspirinE1A-Associated p300 ProteinEP300 protein, humanacetylationagingautophagyEP300longevitymetabolomesalicylate
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