ArticleCell reports2018
The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 184 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed, 2 pooled it
14.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
184 citing papers in PubMed, 2 syntheses or guidelines pooled it, 273 citations in OpenAlex.
- Gabapentinoid Use and Risk of Alzheimer's Disease-Related Dementias: A Systematic Review and Meta-analysis of Observational Studies.Drugs & aging · 2026Pooled it
- Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: Systematic review, meta-analysis, and rationale.Molecular psychiatry · 2022Pooled it
- Trial
- Long-term safety and efficacy of mirogabalin in Asian patients with diabetic peripheral neuropathic pain.Journal of diabetes investigation · 2020Trial
- Targeting Spinal Dorsal Horn Sensitisation in Chronic Pain: Mechanisms and Translational Strategies.Neuroscience bulletin · 2026Review
- Sensory neuron BRAF mediates opioid-induced hyperalgesia and tolerance via presynaptic NMDA receptor hyperactivity.The Journal of clinical investigation · 2026Article
- Emerging Pharmacological Strategies for Trigeminal Neuralgia.CNS drugs · 2026Review
- Possible Signals of Ocular Disorders Associated with Gabapentinoids: A Three-Arm Study.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Synaptic Ca2+ channels and neurexins are linked through direct and indirect binding complexes.Scientific reports · 2026Article
- HIV-1 gp120 Induces Nociceptive Hypersensitivity via α2δ-1-Bound NMDA Receptors at Primary Afferent→Excitatory Neuron Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cardiac α2δ1 C-terminal contributes to left atrial hypertrophy in chronic ischemic heart failure, in association with changes in membrane GluN1 and p-CAMKII/p-HDAC4 signaling.Cell and tissue research · 2026Article
- CACNA2D1 promotes ovulation by regulating ovarian immune cell infiltration.BMC veterinary research · 2026Article
- Calcineurin inhibitor-induced pain syndrome: an uncommon side effect of immunosuppressive therapy after allogeneic hematopoietic stem cell transplant. a case report and review of the literature.Annals of hematology · 2026Review
- Review
- Molecular Partners of Voltage-Gated Calcium Channel β and αThe Journal of membrane biology · 2026Review
- Modulation of NMDA Receptor and TRPM4 Activity in Hippocampal Neurons with the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin.Neurotoxicity research · 2026Article
- α2δ-1-NMDAR1 complex in the hypothalamic paraventricular nucleus mediates anxiety-induced sympathetic hyperactivity.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- EGFR activation sensitizes trigeminal NMDA receptors to promote pain and morphine analgesic tolerance in oral cancer.Science signaling · 2026Article
- Loss of Thy1 in Cortico-Striatal Pathways Alters Response to Dopamine and Gabapentin.ASN neuro · 2026Article
- Pharmacologic Management of Neuropathic Pain After Lumbar Spine Surgery: A Case-Based Review.Orthopedic reviews · 2026Article
124 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 2 countries.
Jinjun ChenCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128, China.
Lingyong LiCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Shao-Rui ChenCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hong ChenCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jing-Dun XieCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Anesthesiology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, China.
Rita E SirriehDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center, Houston, TX 77030, USA.
David M MacLeanDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center, Houston, TX 77030, USA.
Yuhao ZhangCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Meng-Hua ZhouCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Vasanthi JayaramanDepartment of Biochemistry and Molecular Biology, The University of Texas Health Science Center, Houston, TX 77030, USA.
Hui-Lin PanCenter for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: huilinpan@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USThe University of Texas Health Science Center at Houston · USHunan Agricultural University · CN
Funding
HOUSTON AREA MOLECULAR BIOPHYSICS TRAINING PROGRAMT32GM008280 · NIGMS · RICE UNIVERSITY · PI WENSEL, THEODORE G · 1988 to 2023
$8.0MDynamics Of Ligand Gated Ion ChannelsR35GM122528 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Vasanthi Jayaraman · 2017 to 2026
$6.2MMolecular Determinants of Synaptic Plasticity in Chronic PainR01NS101880 · NINDS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Shao-Rui Chen, Hui-Lin Pan · 2017 to 2026
$4.1MMechanisms of Neuronal Plasticity in Neuropathic PainR01GM120844 · NIGMS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PAN, HUI-LIN · 2016 to 2019
$1.6M3D structure and function of Acid Sensing Ion channelsR00NS094761 · NINDS · UNIVERSITY OF ROCHESTER · PI MACLEAN, DAVID MALCOM · 2017 to 2019
$747k3D structure and function of Acid Sensing Ion channelsK99NS094761 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MACLEAN, DAVID MALCOM · 2015 to 2016
$173kNIGMS NIH HHS R01 GM120844NIGMS NIH HHS R35 GM122528NIGMS NIH HHS T32 GM008280NINDS NIH HHS K99 NS094761NINDS NIH HHS R00 NS094761NINDS NIH HHS R01 NS101880
Abstract
α2δ-1, commonly known as a voltage-activated Ca
Indexed as
AnimalsCalcium ChannelsCalcium Channels, L-TypeGabapentinHEK293 CellsHumansMaleMice, KnockoutNeuralgiaPosterior Horn CellsProtein BindingRatsReceptors, N-Methyl-D-AspartateSynapsesCACNA2D1 protein, mouseCacna2d1 protein, ratCalcium ChannelsCalcium Channels, L-TypeGabapentinReceptors, N-Methyl-D-Aspartatechronic paindorsal root ganglionglutamatepregabalinpresynapticsynaptic plasticitysynaptic traffickingsynaptic transmissionthrombospondinvoltage-gated calcium channels
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.