Evidence map›Paper›PMID 29490257›Full record

ArticleBiophysical journal2018

Impact of Tissue Factor Localization on Blood Clot Structure and Resistance under Venous Shear.

Vijay Govindarajan, Shu Zhu, Ruizhi Li, Yichen Lu, Scott L Diamond, Jaques Reifman, Alexander Y Mitrophanov

Open access · hybridAbstract read
In one paragraph

Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Liver Clot after Periodontal Surgery: A Rare Case Report.Journal of pharmacy & bioallied sciences · 2023
    Article
  8. Article
  9. Article
  10. Microfluidics in Haemostasis: A Review.Molecules (Basel, Switzerland) · 2020
    Review
  11. Article
  12. Article
  13. A density-dependent FEM-FCT algorithm with application to modeling platelet aggregation.International journal for numerical methods in biomedical engineering · 2019
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Vijay GovindarajanDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland.
Shu ZhuInstitute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania.
Ruizhi LiInstitute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania.
Yichen LuInstitute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania.
Scott L DiamondInstitute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, Pennsylvania.
Jaques ReifmanDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland. Electronic address: jaques.reifman.civ@mail.mil.
Alexander Y MitrophanovDepartment of Defense Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland.
University of Pennsylvania · USUnited States Army Medical Research and Development Command · USTelemedicine & Advanced Technology Research Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The structure and growth of a blood clot depend on the localization of tissue factor (TF), which can trigger clotting during the hemostatic process or promote thrombosis when exposed to blood under pathological conditions. We sought to understand how the growth, structure, and mechanical properties of clots under flow are shaped by the simultaneously varying TF surface density and its exposure area. We used an eight-channel microfluidic device equipped with a 20- or 100-μm-long collagen surface patterned with lipidated TF of surface densities ∼0.1 and ∼2 molecules/μm

Indexed as

Stress, MechanicalBlood CoagulationBlood PlateletsComputer SimulationFibrinHumansLab-On-A-Chip DevicesModels, TheoreticalShear StrengthThrombinThromboplastinThrombosisVeinsFibrinThrombinThromboplastin

Identifiers

PMID29490257
PMCPMC5984989
OpenAlexW2790187917

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.