ArticleBiophysical journal2018
Theory of Epithelial Cell Shape Transitions Induced by Mechanoactive Chemical Gradients.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Spatial patterning of contractility by a self-organized mechanogen activity gradient underlies Drosophila gastrulation.Nature communications · 2026Article
- Equations describing semi-confluent cell growth (II) colony formation on a flat surface.European biophysics journal : EBJ · 2025Article
- Construction of primary chassis cells with efficient protein expression in Thermus thermophilus.Microbial cell factories · 2025Article
- Mechano-gradients drive morphogen-noise correction to ensure robust patterning.Science advances · 2024Article
- Three-dimensional chiral morphodynamics of chemomechanical active shells.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Modelling the Collective Mechanical Regulation of the Structure and Morphology of Epithelial Cell Layers.Frontiers in cell and developmental biology · 2022Article
- Autonomous epithelial folding induced by an intracellular mechano-polarity feedback loop.PLoS computational biology · 2021Article
- 3D viscoelastic drag forces contribute to cell shape changes during organogenesis in the zebrafish embryo.Cells & development · 2021Article
- Modeling mechanochemical pattern formation in elastic sheets of biological matter.The European physical journal. E, Soft matter · 2021Article
- Programmed and self-organized flow of information during morphogenesis.Nature reviews. Molecular cell biology · 2021Review
- A free boundary mechanobiological model of epithelial tissues.Proceedings. Mathematical, physical, and engineering sciences · 2020Article
- Nonlinear and nonlocal elasticity in coarse-grained differential-tension models of epithelia.Physical review. E · 2019Article
- Tissue Flow Induces Cell Shape Changes During Organogenesis.Biophysical journal · 2018Article
- The noisy basis of morphogenesis: Mechanisms and mechanics of cell sheet folding inferred from developmental variability.PLoS biology · 2018Article
- Cell-cell adhesion interface: orthogonal and parallel forces from contraction, protrusion, and retraction.F1000Research · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Cell shape is determined by a balance of intrinsic properties of the cell as well as its mechanochemical environment. Inhomogeneous shape changes underlie many morphogenetic events and involve spatial gradients in active cellular forces induced by complex chemical signaling. Here, we introduce a mechanochemical model based on the notion that cell shape changes may be induced by external diffusible biomolecules that influence cellular contractility (or equivalently, adhesions) in a concentration-dependent manner-and whose spatial profile in turn is affected by cell shape. We map out theoretically the possible interplay between chemical concentration and cellular structure. Besides providing a direct route to spatial gradients in cell shape profiles in tissues, we show that the dependence on cell shape helps create robust mechanochemical gradients.
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