ArticleBiophysical journal2018
Stochastic Model of Maturation and Vesicular Exchange in Cellular Organelles.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Morphological determinants of glycosylation efficiency in Golgi cisternae.PLoS computational biology · 2026Article
- Deterministic early endosomal maturations emerge from a stochastic trigger-and-convert mechanism.Nature communications · 2023Article
- Robustness and Universality in Organelle Size Control.Physical review letters · 2023Article
- Stochastic reaction networks in dynamic compartment populations.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Article
- A novel combinatorial approach of quantitative microscopy and in silico modeling deciphers Arf1-dependent Golgi size regulation.The European physical journal. E, Soft matter · 2019Article
- Postsynaptic Stability and Variability Described by a Stochastic Model of Endosomal Trafficking.Frontiers in cellular neuroscience · 2019Article
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Authors and funding
2 authors.
Funding
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Abstract
The dynamical organization of membrane-bound organelles along intracellular transport pathways relies on vesicular exchange between organelles and on the maturation of the organelle's composition by enzymatic reactions or exchange with the cytoplasm. The relative importance of each mechanism in controlling organelle dynamics remains controversial, in particular for transport through the Golgi apparatus. Using a stochastic model, we identify two classes of dynamical behavior that can lead to full maturation of membrane-bound compartments. In the first class, maturation corresponds to the stochastic escape from a steady state in which export is dominated by vesicular exchange, and is very unlikely for large compartments. In the second class, it occurs in a quasi-deterministic fashion and is almost size independent. Whether a system belongs to the first or second class is largely controlled by homotypic fusion.
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