ArticleBiophysical journal2018
Spatial Fluctuations at Vertices of Epithelial Layers: Quantification of Regulation by Rho Pathway.
Article in Biophysical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Intrinsic cell rheology drives junction maturation.Nature communications · 2022Article
- Interplay between cell height variations and planar pulsations in epithelial monolayers.The European physical journal. E, Soft matter · 2022Article
- Avalanches during epithelial tissue growth; Uniform Growth and a drosophila eye disc model.PLoS computational biology · 2022Article
- Sculpting tissues by phase transitions.Nature communications · 2022Review
- Article
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Authors and funding
8 authors.
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Abstract
In living matter, shape fluctuations induced by acto-myosin are usually studied in vitro via reconstituted gels, whose properties are controlled by changing the concentrations of actin, myosin, and cross-linkers. Such an approach deliberately avoids consideration of the complexity of biochemical signaling inherent to living systems. Acto-myosin activity inside living cells is mainly regulated by the Rho signaling pathway, which is composed of multiple layers of coupled activators and inhibitors. Here, we investigate how such a pathway controls the dynamics of confluent epithelial tissues by tracking the displacements of the junction points between cells. Using a phenomenological model to analyze the vertex fluctuations, we rationalize the effects of different Rho signaling targets on the emergent tissue activity by quantifying the effective diffusion coefficient, and the persistence time and length of the fluctuations. Our results reveal an unanticipated correlation between layers of activation/inhibition and spatial fluctuations within tissues. Overall, this work connects regulation via biochemical signaling with mesoscopic spatial fluctuations, with potential application to the study of structural rearrangements in epithelial tissues.
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