Evidence map›Paper›PMID 29490167›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

New maresin conjugates in tissue regeneration pathway counters leukotriene D

Nan Chiang, Ian R Riley, Jesmond Dalli, Ana R Rodriguez, Bernd W Spur, Charles N Serhan

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Maresins.Biomolecules · 2026
    Review
  4. Impacts of Oxylipins on ischemic stroke: from pathophysiology to clinical phenotypes.Metabolomics : Official journal of the Metabolomic Society · 2025
    Review
  5. Linking Lipid Metabolism and Immune Function: New Insights into Chronic Respiratory Diseases.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Review
  6. Review
  7. Cysteinyl Leukotrienes in Allergic Inflammation.Annual review of pathology · 2025
    Review
  8. Review
  9. Maresin-2 promotes mucosal repair and has therapeutic potential when encapsulated in thermostable nanoparticles.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Molecular Pharmacology of Inflammation Resolution in Atherosclerosis.International journal of molecular sciences · 2022
    Review
  11. Article
  12. Protective Potential of Maresins in Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2022
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Frontiers in immunology · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Nan ChiangDepartment of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ian R RileyDepartment of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Jesmond DalliDepartment of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ana R RodriguezDepartment of Cell Biology, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.
Bernd W SpurDepartment of Cell Biology, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.
Charles N SerhanDepartment of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Brigham and Women's Hospital · USRowan University · USHarvard University · USWilliam Harvey Research Institute · GB

Funding

Resolution Mechanisms in Acute Inflammation: Resolution PharmacologyP01GM095467 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2011 to 2020
$14.8M
BLOOD CELL LIPOXYGENASE PRODUCTS: FORMATION AND ACTIONR01GM038765 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 1992 to 2020
$4.9M
NIGMS NIH HHS P01 GM095467NIGMS NIH HHS R01 GM038765
6 · The paper itself

Abstract

Resolution of acute inflammation is governed, in part, by lipid mediator class switching from proinflammatory eicosanoids to specialized proresolving mediators, including a recently identified new pathway of mediators, termed maresin conjugates in tissue regeneration (MCTR), which includes MCTR1, MCTR2, and MCTR3. Here, we addressed whether each MCTR can impact the known vascular actions of cysteinyl leukotrienes. Leukotriene D

Indexed as

PhagocytosisRegenerationAnimalsBlood VesselsCells, CulturedCHO CellsCiona intestinalisCricetinaeCricetulusDocosahexaenoic AcidsHumansLeukotriene D4MacrophagesReceptors, LeukotrieneDocosahexaenoic AcidsLeukotriene D4leukotriene D4 receptorReceptors, Leukotrieneinflammationleukocytelipoxygenaseomega-3resolutionresolvin

Identifiers

PMID29490167
PMCPMC5998978
OpenAlexW2790614587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.