Evidence map›Paper›PMID 29490162›Full record

ReviewAnnual review of immunology2018

Rebooting Human Immunology.

Mark M Davis, Petter Brodin

Abstract readReview
In one paragraph

Review in Annual review of immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Immune Aging is an Independent Risk Factor for Cardiovascular Disease.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Age-dependent cytokine surge in blood precedes cancer diagnosis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Review
  6. Article
  7. The Microbe, the Infection Enigma, and the Host.Annual review of microbiology · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Human CCR6bioRxiv : the preprint server for biology · 2023
    Article
  14. Article
  15. Article
  16. Antibody repertoire sequencing analysis.Acta biochimica et biophysica Sinica · 2022
    Review
  17. Article
  18. Milestones in acute GVHD pathophysiology.Frontiers in immunology · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mark M DavisDepartment of Microbiology and Immunology, The Howard Hughes Medical Institute, and the Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California 94305, USA; email: mmdavis@stanford.edu.
Petter BrodinScience for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, 17121 Solna, Sweden.

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
NIAID NIH HHS U19 AI057229
6 · The paper itself

Abstract

Recent progress in both conceptual and technological approaches to human immunology have rejuvenated a field that has long been in the shadow of the inbred mouse model. This is a healthy development both for the clinical relevance of immunology and for the fact that it is a way to gain access to the wealth of phenomenology in the many human diseases that involve the immune system. This is where we are likely to discover new immunological mechanisms and principals, especially those involving genetic heterogeneity or environmental influences that are difficult to model effectively in inbred mice. We also suggest that there are likely to be novel immunological mechanisms in long-lived, less fecund mammals such as human beings since they must remain healthy far longer than short-lived rodents in order for the species to survive.

Indexed as

ImmunityAnimalsBiological EvolutionBiological Variation, PopulationB-LymphocytesClonal DeletionHost-Pathogen InteractionsHumansImmune SystemImmunologic MemoryModels, AnimalReceptors, Antigen, T-CellT-LymphocytesReceptors, Antigen, T-CellCMVhuman evolutionhuman immunologysystems immunology

Identifiers

PMID29490162
PMCPMC6677260

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.