ArticleAngewandte Chemie (International ed. in English)2018
Selective Hydrogen Atom Abstraction through Induced Bond Polarization: Direct α-Arylation of Alcohols through Photoredox, HAT, and Nickel Catalysis.
Article in Angewandte Chemie (International ed. in English), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 211 citations in OpenAlex.
- Decatungstate-photocatalyzed transfer hydrogenation of unsaturated compounds using alcohol as the hydrogen source.Nature communications · 2026Article
- COAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Kinetics, Thermodynamics, and Emergence in Stereoediting Reactions.Accounts of chemical research · 2025Article
- Establishing Thermodynamic Graphs of Nitrogenous Radical Cations Abstracting Hydrogen Atoms and Their Applications in Photoredox Reactions.Molecules (Basel, Switzerland) · 2025Article
- A modular approach to catalytic stereoselective synthesis of chiral 1,2-diols and 1,3-diols.Nature communications · 2025Article
- Synthesis of alcohols: streamlined C1 to CChemical science · 2024Article
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- O-H bond activation of β,γ-unsaturated oximesChemical science · 2023Article
- First Reusable Catalyst for the Reductive Coupling Reaction of Organohalides with Aldehydes.ACS omega · 2023Article
- Recent Advances in C-H Functionalisation through Indirect Hydrogen Atom Transfer.Molecules (Basel, Switzerland) · 2023Review
- Oxetane Synthesis via Alcohol C-H Functionalization.Journal of the American Chemical Society · 2023Article
- Unlocking the Nucleophilicity of Strong Alkyl C-H Bonds via Cu/Cr Catalysis.ACS central science · 2023Article
- Variable structure diversification by multicatalysis: the case of alcohols.Chemical communications (Cambridge, England) · 2023Review
- Fragile intermediate identification and reactivity elucidation in electrochemical oxidative α-C(spChemical science · 2023Article
- Organo-photocatalytic C-H bond oxidation: an operationally simple and scalable method to prepare ketones with ambient air.RSC advances · 2023Article
- Visible-light-induced selective defluoroalkylations of polyfluoroarenes with alcohols.Chemical science · 2023Article
- Direct Synthesis of α-Aryl-α-Trifluoromethyl Alcohols via Nickel Catalyzed Cross-Electrophile Coupling.Angewandte Chemie (International ed. in English) · 2022Article
- A switchable redox annulation of 2-nitroarylethanols affordingChemical science · 2022Article
- Aliphatic C-H Functionalization Using PyridineACS catalysis · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The combination of nickel metallaphotoredox catalysis, hydrogen atom transfer catalysis, and a Lewis acid activation mode, has led to the development of an arylation method for the selective functionalization of alcohol α-hydroxy C-H bonds. This approach employs zinc-mediated alcohol deprotonation to activate α-hydroxy C-H bonds while simultaneously suppressing C-O bond formation by inhibiting the formation of nickel alkoxide species. The use of Zn-based Lewis acids also deactivates other hydridic bonds such as α-amino and α-oxy C-H bonds. This approach facilitates rapid access to benzylic alcohols, an important motif in drug discovery. A 3-step synthesis of the drug Prozac exemplifies the utility of this new method.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.