ArticleThe Journal of nutrition2018
Higher Mediterranean Diet Quality Scores and Lower Body Mass Index Are Associated with a Less-Oxidized Plasma Glutathione and Cysteine Redox Status in Adults.
Article in The Journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
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- Immunonutrition: Another Player on the MASLD Field.International journal of molecular sciences · 2025Review
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- Association between healthy dietary patterns and markers of oxidative stress in the Sister Study.European journal of nutrition · 2024Article
- Mechanistic exploration of Yiqi Liangxue Shengji prescription on restenosis after balloon injury by integrating metabolomics with network pharmacology.Pharmaceutical biology · 2023Article
- The synthesis and evaluation of thiolated alginate as the barrier to block nutrient absorption on small intestine for body-weight control.Bioengineering & translational medicine · 2023Article
- Effect of Alpha Lipoic Acid Supplementation on Oxidative Stress and Lipid Parameters in Women Diagnosed with Low-Grade Squamous Intraepithelial Lesions (LSILs): A Double-Blind, Randomized, Placebo-Controlled Trial.Antioxidants (Basel, Switzerland) · 2023Article
- Glutathione: Lights and Shadows in Cancer Patients.Biomedicines · 2023Review
- The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression.Amino acids · 2023Article
- Are Nutritional Patterns among Polish Hashimoto Thyroiditis Patients Differentiated Internally and Related to Ailments and Other Diseases?Nutrients · 2021Article
- Extracellular cystine influences human preadipocyte differentiation and correlates with fat mass in healthy adults.Amino acids · 2021Article
- Glutathione Participation in the Prevention of Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2021Review
- Article
- The association between deficiency of nutrient intake and resting metabolic rate in overweight and obese women: a cross-sectional study.BMC research notes · 2021Article
- Physical Fitness but Not Diet Quality Distinguishes Lean and Normal Weight Obese Adults.Journal of the Academy of Nutrition and Dietetics · 2020Article
- Validation of a simplified procedure for convenient and rapid quantification of reduced and oxidized glutathione in human plasma by liquid chromatography tandem mass spectrometry analysis.Biomedical chromatography : BMC · 2020Article
- Pre-stroke adherence to a Mediterranean diet pattern is associated with lower acute ischemic stroke severity: a cross-sectional analysis of a prospective hospital-register study.BMC neurology · 2020Article
- Cobalt Oxyhydroxide-prompted Synthesis of Fluorescent Polydopamine Nanoparticles for Glutathione Detection.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2020Article
- Plasma cysteine/cystine and glutathione/glutathione disulfide redox potentials in HIV and COPD patients.Free radical biology & medicine · 2019Article
- Plasma High-Resolution Metabolomics Differentiates Adults with Normal Weight Obesity from Lean Individuals.Obesity (Silver Spring, Md.) · 2019Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Background: Both systemic redox status and diet quality are associated with risk outcomes in chronic disease. It is not known, however, the extent to which diet quality influences plasma thiol/disulfide redox status. Objective: The purpose of this study was to investigate the influence of diet, as measured by diet quality scores and other dietary factors, on systemic thiol/disulfide redox status. Methods: We performed a cross-sectional study of 685 working men and women (ages ≥18 y) in Atlanta, GA. Diet was assessed by 3 diet quality scores: the Alternative Healthy Eating Index (AHEI), Dietary Approaches to Stop Hypertension (DASH), and the Mediterranean Diet Score (MDS). We measured concentrations of plasma glutathione (GSH), cysteine, their associated oxidized forms [glutathione disulfide (GSSG) and cystine (CySS), respectively], and their redox potentials (EhGSSG and EhCySS) to determine thiol/disulfide redox status. Linear regression modeling was performed to assess relations between diet and plasma redox after adjustment for age, body mass index (BMI), sex, race, and history of chronic disease. Results: MDS was positively associated with plasma GSH (β = 0.02; 95% CI: 0.003, 0.03) and total GSH (GSH + GSSG) (β = 0.02; 95% CI: 0.003, 0.03), and inversely associated with the CySS:GSH ratio (β = -0.02; 95% CI: -0.04, -0.004). There were significant independent associations between individual MDS components (dairy, vegetables, fish, and monounsaturated fat intake) and varying plasma redox indexes (P < 0.05). AHEI and DASH diet quality indexes and other diet factors of interest were not significantly correlated with plasma thiol and disulfide redox measures. Conclusion: Adherence to the Mediterranean diet was significantly associated with a favorable plasma thiol/disulfide redox profile, independent of BMI, in a generally healthy working adult population. Although longitudinal studies are warranted, these findings contribute to the feasibility of targeting a Mediterranean diet to improve plasma redox status.
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