ArticleThe Journal of antimicrobial chemotherapy2018
Defining the appropriateness and inappropriateness of antibiotic prescribing in primary care.
Article in The Journal of antimicrobial chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 5 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Inappropriate antibiotic prescribing in Ethiopian hospitals: a systematic review.International journal of clinical pharmacy · 2026Pooled it
- Antimicrobial prescription pattern and appropriateness for respiratory tract infection in outpatients: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Antibiotics for treatment of sore throat in children and adults.The Cochrane database of systematic reviews · 2021Pooled it
- Improving antibiotic use through behaviour change: a systematic review of interventions evaluated in low- and middle-income countries.Health policy and planning · 2021Pooled it
- Health care costs of influenza-related episodes in high income countries: A systematic review.PloS one · 2018Pooled it
- Pelargonium sidoides extract (EPs® 7630) versus usual care for acute bronchitis in Swiss primary care (PHYTOBRONCH): a pragmatic, open-label, randomised controlled trial.NPJ primary care respiratory medicine · 2026Trial
- Patterns of Antibiotic Dispensing Among New Zealand Children: A Linkage Study.Pharmacoepidemiology and drug safety · 2026Article
- Antibiotic prescribing in people with and without diabetes: a population-based matched cohort study.JAC-antimicrobial resistance · 2026Article
- The Applicability of AWaRe-Based Antibiotic Quality Indicators to Assess the Appropriateness of Antibiotic Prescribing in Primary Healthcare in South Africa: A Multicentre Point Prevalence Study and Implications for the Future.Antibiotics (Basel, Switzerland) · 2026Article
- A survey of parental health-seeking behaviour, knowledge, and expectations around ear infection symptoms in children.BJGP open · 2026Article
- Article
- Appropriateness of Antibiotic Prescription Among Children Under 5 Years: A Cross-Sectional Study in a Ghanaian Regional Hospital.Health science reports · 2025Article
- A retrospective clinical evaluation of the quality of antibiotic use in treating ear, nose and throat infections in ambulatory care setting of a teaching hospital in Ghana: findings and implications.BMC infectious diseases · 2025Article
- Prevalence of Antibiotic Prescribing for Acute Respiratory Tract Infection in Telehealth Versus Face-to-Face Consultations: Cross-Sectional Analysis of General Practice Registrars' Clinical Practice.Journal of medical Internet research · 2025Article
- Changing the antibiotic prescribing of Australian general practice registrars' for acute respiratory tract infections: a non-randomized controlled trial.Family practice · 2025Article
- Associations between maternal body mass index and childhood infections in UK primary care: findings from the Born in Bradford birth cohort study.Archives of disease in childhood · 2024Article
- Identifying AWaRe indicators for appropriate antibiotic use: a narrative review.The Journal of antimicrobial chemotherapy · 2024Review
- Appropriateness of intended antibiotic prescribing using clinical case vignettes in primary care, and related factors.The European journal of general practice · 2024Article
- Article
- Temporal patterns of antibiotic prescribing for sore throat, otitis media, and sinusitis: a longitudinal study of general practitioner registrars.Family practice · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To assess the appropriateness of prescribing systemic antibiotics for different clinical conditions in primary care, and to quantify 'ideal' antibiotic prescribing proportions in conditions for which antibiotic treatment is sometimes but not always indicated. Methods: Prescribing guidelines were consulted to define the appropriateness of antibiotic therapy for the conditions that resulted in antibiotic prescriptions between 2013 and 2015 in The Health Improvement Network (THIN) primary care database. The opinions of subject experts were then formally elicited to quantify ideal antibiotic prescribing proportions for 10 common conditions. Results: Of the antibiotic prescriptions in THIN, 52.5% were for conditions that could be assessed using prescribing guidelines. Among these, the vast majority of prescriptions (91.4%) were for conditions where antibiotic appropriateness is conditional on patient-specific indicators. Experts estimated low ideal prescribing proportions in acute, non-comorbid presentations of many of these conditions, such as cough (10% of patients), rhinosinusitis (11%), bronchitis (13%) and sore throat (13%). Conversely, antibiotics were believed to be appropriate in 75% of non-pregnant women with non-recurrent urinary tract infection. In impetigo and acute exacerbation of chronic obstructive pulmonary disease, experts clustered into distinct groups that believed in either high or low prescribing. Conclusions: In English primary care, most antibiotics are prescribed for conditions that only sometimes require antibiotic treatment, depending on patient-specific indicators. Experts estimated low ideal prescribing proportions in many of these conditions. Incomplete prescribing guidelines and disagreement about prescribing in some conditions highlight further research needs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.