ArticleJournal of applied oral science : revista FOB2018
Influence of Helicobacter pylori culture supernatant on the ecological balance of a dual-species oral biofilm.
Article in Journal of applied oral science : revista FOB, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Cross-organ microbes modulate host upper gastrointestinal health and disease via the oral-gastric microbiome axis.Frontiers in cellular and infection microbiology · 2026Review
- Association ofMicroorganisms · 2025Review
- Oral pathogens meet the gut microbiome: new mechanistic insights on systemic disease.Frontiers in cellular and infection microbiology · 2025Review
- Polymicrobial interactions ofJournal of oral microbiology · 2025Review
- Helicobacter pylori in oral cavity: current knowledge.Clinical and experimental medicine · 2024Review
- Review
- Review
- Proteobacteria and Firmicutes Secreted Factors Exert Distinct Effects onMetabolites · 2022Article
- Procyanidins and Their Therapeutic Potential against Oral Diseases.Molecules (Basel, Switzerland) · 2022Review
- The interactions between oral-gut axis microbiota andFrontiers in cellular and infection microbiology · 2022Review
- Efficient inhibition of Cronobacter biofilms by chitooligosaccharides of specific molecular weight.World journal of microbiology & biotechnology · 2019Article
- Influence of Probiotic Culture Supernatants on In Vitro Biofilm Formation of Staphylococci.European journal of microbiology & immunology · 2018Article
- Nanocomposites Based on Biodegradable Polymers.Materials (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dental caries is a chronic progressive disease occurring in the tooth hard tissue due to multiple factors, in which bacteria are the initial cause. Both Streptococcus mutans and Streptococcus sanguinis are main members of oral biofilm. Helicobacter pylori may also be detected in dental plaque, playing an important role in the development of dental caries.
objectiveThe aim of this study was to investigate the effect of H. pylori culture supernatant on S. mutans and S. sanguinis dual-species biofilm and to evaluate its potential ability on affecting dental health. MATERIAL AND
methodsThe effect of H. pylori supernatant on single-species and dual-species biofilm was measured by colony forming units counting and fluorescence in situ hybridization (FISH) assay, respectively. The effect of H. pylori supernatant on S. mutans and S. sanguinis extracellular polysaccharides (EPS) production was measured by both confocal laser scanning microscopy observation and anthrone-sulfuric acid method. The effect of H. pylori supernatant on S. mutans gene expression was measured by quantitative real-time PCR (qRT-PCR) assays.
resultsH. pylori supernatant could inhibit both S. mutans and S. sanguinis biofilm formation and EPS production. S. sanguinis inhibition rate was significantly higher than that of S. mutans. Finally, S. mutans bacteriocin and acidogenicity related genes expression were affected by H. pylori culture supernatant.
conclusionOur results showed that H. pylori could destroy the balance between S. mutans and S. sanguinis in oral biofilm, creating an advantageous environment for S. mutans, which became the dominant bacteria, promoting the formation and development of dental caries.
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Registered trials
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