ArticlePloS one2018
An evaluation of longitudinal changes in serum uric acid levels and associated risk of cardio-metabolic events and renal function decline in gout.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- The Association Between Serum Uric Acid Levels and the 10-Year Prospective Risk of Dyslipidemia: A Cohort Study From Healthy Heart Project (YHHP).Health science reports · 2025Article
- Association between serum urate levels and all-cause mortality, cardiovascular and renal outcomes among gout patients in Singapore.BMC rheumatology · 2024Article
- Effect of gout and diabetic kidney disease on renal cancer development in Korea.Clinical kidney journal · 2024Article
- Spilanthes filicaulis (Schumach. & Thonn.) C.D. Adams leaves protects against streptozotocin-induced diabetic nephropathy.PloS one · 2024Article
- Factors for achieving target serum uric acid levels after initiating urate-lowering therapy in patients with gout: results from the ULTRA registry.Scientific reports · 2023Article
- Change in Serum Uric Acid is a Useful Predictor of All-Cause Mortality among Community-Dwelling Persons.International journal of analytical chemistry · 2023Article
- Prevalence of Obesity in Newly Onset Diabetes Mellitus and Its Relationship with Uric Acid: An Indian Cross-Sectional Study.International journal of general medicine · 2023Article
- Atrial Fibrillation Risk and Urate-Lowering Therapy in Patients with Gout: A Cohort Study Using a Clinical Database.Biomedicines · 2022Article
- High serum uric acid trajectories are associated with risk of myocardial infarction and all-cause mortality in general Chinese population.Arthritis research & therapy · 2022Article
- Article
- Prevalence of Hyperuricemia and the Relationship Between Serum Uric Acid and Hypertension in New Onset Diabetic Patients: A Cross-Sectional Indian Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
- Modelling of longitudinal data to predict cardiovascular disease risk: a methodological review.BMC medical research methodology · 2021Article
- Serum Urate Trajectory in Young Adulthood and Incident Cardiovascular Disease Events by Middle Age: CARDIA Study.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Quantification of uric acid in vasculature of patients with gout using dual-energy computed tomography.World journal of radiology · 2020Article
- Empagliflozin Attenuates Hyperuricemia by Upregulation of ABCG2 via AMPK/AKT/CREB Signaling Pathway in Type 2 Diabetic Mice.International journal of biological sciences · 2020Article
- Risk of Acute Myocardial Infarction Among New Users of Allopurinol According to Serum Urate Level: A Nested Case-Control Study.Journal of clinical medicine · 2019Article
- Hyperuricemia treatment in acute heart failure patients does not improve their long-term prognosis: A propensity score matched analysis from the AHEAD registry.Clinical cardiology · 2019Article
- Relationship between serum uric acid and hypertension: a cross-sectional study in Bangladeshi adults.Scientific reports · 2019Article
- Serum uric acid could be served as an independent marker for increased risk and severity of ascending aortic dilatation in Behçet's disease patients.Journal of clinical laboratory analysis · 2019Article
- Lack of Associations between Elevated Serum Uric Acid and Components of Metabolic Syndrome Such as Hypertension, Dyslipidemia, and T2DM in Overweight and Obese Chinese Adults.Journal of diabetes research · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveGout patients have a high burden of co-morbid conditions including diabetes mellitus (DM), chronic kidney disease (CKD), and cardiovascular disease (CVD). We sought to evaluate the association between changes in serum uric acid (SUA) levels over time and the risk of incident DM, CVD, and renal function decline in gout patients.
methodsAn observational cohort study was conducted among enrollees of private health insurance programs in the US between 2004 and 2015. Gout patients were included on the index date of a SUA measurement ≥6.8 mg/dl. The exposure of interest was cumulative change in SUA levels from baseline. Hazard ratios (HR) and 95% confidence intervals (CI) for incident DM, incident CVD, and renal function decline (≥30% reduction in glomerular filtration rate) were derived using marginal structural models with stabilized inverse probability weights accounting for baseline confounders (age, gender, co-morbidities, co-medications) and time-varying confounders (serum creatinine, blood urea nitrogen, glycated hemoglobin).
resultsAmong 26,341 patients with gout, the average age was 62, 75% were men, and the median baseline SUA was 8.6 mg/dl (interquartile range 7.7 to 9.5). The incidence rates/100 person-years (95% CI) were 1.63 (1.51-1.75) for DM, 0.77 (0.70-0.84) for CVD, and 4.32 (4.14-4.49) for renal function decline. The adjusted HR (95% CI) per 3 mg/dl reduction in SUA, corresponding on average to achieving the target level of <6 mg/dl in this population, was 1.04 (0.92-1.17) for DM, 1.07 (0.89-1.29) for CVD, and 0.85 (0.78-0.92) for renal function decline.
conclusionsReduction in SUA in patients with gout may be associated with a reduced risk of renal function decline, but not with DM or CVD.
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