ArticlePloS one2018
Identification and characterization of microRNAs in the intestinal tissues of sheep (Ovis aries).
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Maternal undernutrition inhibits fetal rumen development: novel miRNA-736-mediated dual targeting of E2F2 and MYBL2 in sheep.Journal of animal science and biotechnology · 2026Article
- Genomic analysis association of tolerance to heat stress in subtropical Egyptian goats Raised in hot dry environment.BMC genomics · 2025Article
- Dynamic microRNA expression profiles in goat ovarian tissues before and after pregnancy.Journal of animal science · 2025Article
- Analysis of miRNAs in milk of four livestock species.BMC genomics · 2024Article
- Characterization of MicroRNA expression profiles in the ovarian tissue of goats during the sexual maturity period.Journal of ovarian research · 2023Article
- MicroRNAs in Ruminants and Their Potential Role in Nutrition and Physiology.Veterinary sciences · 2023Review
- Developmental Alterations of Colonic microRNA Profiles Imply Potential Biological Functions in Kid Goats.Animals : an open access journal from MDPI · 2022Article
- Age-dependent changes of hindgut microbiota succession and metabolic function of Mongolian cattle in the semi-arid rangelands.Frontiers in microbiology · 2022Article
- MicroRNA and circular RNA profiling in the deposited fat tissue of Sunite sheep.Frontiers in veterinary science · 2022Article
- Identification of Ovine Serum miRNAs Following Bacterial Lipopolysaccharide Challenge.International journal of molecular sciences · 2020Article
- The microbial biogeography of the gastrointestinal tract of preterm and term lambs.Scientific reports · 2020Article
- Identification and Profiling of Pituitary microRNAs of Sheep during Anestrus and Estrus Stages.Animals : an open access journal from MDPI · 2020Article
- Characterization of Sheep Milk Extracellular Vesicle-miRNA by Sequencing and Comparison with Cow Milk.Animals : an open access journal from MDPI · 2020Article
- Article
- In silico identification of conserved miRNAs and their selective target gene prediction in indicine (Bos indicus) cattle.PloS one · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sheep are small ruminants, and their long intestines exhibit high digestive and absorptive capacity in many different rearing conditions; however, the genetic bases of this characteristic remains unclear. MicroRNAs (miRNAs) play a major role in maintaining both intestinal morphological structure as well as in regulating the physiological functions of this organ. However, no study has reported on the miRNA expression profile in the intestinal tissues of sheep. Here, we analyzed and identified the miRNA expression profile of three different intestinal tissues (i.e., duodenum, cecum, and colon) of sheep (Ovis aries) using high-throughput sequencing and bioinformatic methods. In total, 106 known miRNAs were identified, 458 conserved miRNAs were detected, 192 unannotated novel miRNAs were predicted, and 195 differentially expressed miRNAs were found between the different tissues. Additionally, 3,437 candidate target genes were predicted, and 17 non-redundant significantly enriched GO terms were identified using enrichment analysis. A total of 99 candidate target genes were found to significantly enriched in 4 KEGG biological pathways. A combined regulatory network was constructed based on 92 metabolism-related candidate target genes and 65 differentially expressed miRNAs, among which 7 miRNAs were identified as hub miRNAs. Via these mechanisms, miRNAs may play a role in maintaining intestinal homeostasis and metabolism. This study helps to further explain the mechanisms that underlie differences in tissue morphology and function in three intestinal segments of sheep.
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