ArticlePloS one2018
Phylodynamics and evolutionary epidemiology of African swine fever p72-CVR genes in Eurasia and Africa.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- African tick-borne viruses: A systematic review of diversity, epidemiology, clinical impact, and one health strategies.Veterinary research communications · 2026Pooled it
- African Swine Fever Virus Circulation between Tanzania and Neighboring Countries: A Systematic Review and Meta-Analysis.Viruses · 2021Pooled it
- An attenuated African swine fever virus with deletions of theJournal of virology · 2025Article
- Phylogenomic analysis of African swine fever virus from the Philippines.Archives of virology · 2025Article
- Host-Calibrated Time Tree Caps the Age of Giant Viruses.Molecular biology and evolution · 2025Article
- Detection of African Swine Fever Virus Genotype II in West Africa (2020) and Its Co-Circulation With Endemic Genotype I: Implications for Pig Production.Transboundary and emerging diseases · 2025Article
- Complete genome analysis of the African swine fever virus genotypes II and IX responsible for the 2021 and 2023 outbreaks in Rwanda.Frontiers in veterinary science · 2025Article
- The Comparative Full-Length Genome Characterization of African Swine Fever Virus Detected in Thailand.Animals : an open access journal from MDPI · 2024Article
- A proposed update of African swine fever virus (genotype II) subgenotyping based on the central variable region (CVR) of Russian isolates.Archives of virology · 2024Article
- African swine fever; insights into genomic aspects, reservoirs and transmission patterns of virus.Frontiers in veterinary science · 2024Review
- A Guide to Molecular Characterization of Genotype II African Swine Fever Virus: Essential and Alternative Genome Markers.Microorganisms · 2023Review
- A multi gene-approach genotyping method identifies 24 genetic clusters within the genotype II-European African swine fever viruses circulating from 2007 to 2022.Frontiers in veterinary science · 2023Article
- The Potential Role of Wild Suids in African Swine Fever Spread in Asia and the Pacific Region.Viruses · 2022Review
- Genetic Characterization of African Swine Fever Virus in Various Outbreaks in Central and Southern Vietnam During 2019-2021.Current microbiology · 2022Article
- The baseline immunological and hygienic status of pigs impact disease severity of African swine fever.PLoS pathogens · 2022Article
- Molecular characterization of African swine fever viruses from Burkina Faso, 2018.BMC veterinary research · 2022Article
- African Swine Fever Survey in a European Context.Pathogens (Basel, Switzerland) · 2022Article
- Toosendanin suppresses African swine fever virus replication through upregulating interferon regulatory factor 1 in porcine alveolar macrophage cultures.Frontiers in microbiology · 2022Article
- Article
- Identification of African swine fever virus-like elements in the soft tick genome provides insights into the virus' evolution.BMC biology · 2020Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
African swine fever (ASF) is a complex infectious disease of swine that constitutes devastating impacts on animal health and the world economy. Here, we investigated the evolutionary epidemiology of ASF virus (ASFV) in Eurasia and Africa using the concatenated gene sequences of the viral protein 72 and the central variable region of isolates collected between 1960 and 2015. We used Bayesian phylodynamic models to reconstruct the evolutionary history of the virus, to identify virus population demographics and to quantify dispersal patterns between host species. Results suggest that ASFV exhibited a significantly high evolutionary rate and population growth through time since its divergence in the 18th century from East Africa, with no signs of decline till recent years. This increase corresponds to the growing pig trade activities between continents during the 19th century, and may be attributed to an evolutionary drift that resulted from either continuous circulation or maintenance of the virus within Africa and Eurasia. Furthermore, results implicate wild suids as the ancestral host species (root state posterior probability = 0.87) for ASFV in the early 1700s in Africa. Moreover, results indicate the transmission cycle between wild suids and pigs is an important cycle for ASFV spread and maintenance in pig populations, while ticks are an important natural reservoir that can facilitate ASFV spread and maintenance in wild swine populations. We illustrated the prospects of phylodynamic methods in improving risk-based surveillance, support of effective animal health policies, and epidemic preparedness in countries at high risk of ASFV incursion.
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