ArticlePloS one2018
Evaluation of the novel avocado/soybean unsaponifiable Arthrocen to alter joint pain and inflammation in a rat model of osteoarthritis.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Joint Dysfunctionality Alleviation along with Systemic Inflammation Reduction Following Arthrocen Treatment in Patients with Knee Osteoarthritis: A Randomized Double-Blind Placebo-Controlled Clinical Trial.Medicina (Kaunas, Lithuania) · 2022Trial
- Article
- Progress in the treatment of Osteoarthritis with avocado-soybean unsaponifiable.Inflammopharmacology · 2024Review
- Osteoarthritis complications and the recent therapeutic approaches.Inflammopharmacology · 2021Review
- Comparative effectiveness of two methods for inducing osteoarthritis in a novel animal model, the Diannan small-ear pig.Journal of orthopaedic surgery and research · 2021Article
- Analgesic and Anti-Inflammatory Effects ofPlants (Basel, Switzerland) · 2020Article
- Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis.Nutrients · 2020Article
- Unraveling Natural Products' Role in Osteoarthritis Management-An Overview.Antioxidants (Basel, Switzerland) · 2020Review
- Review
- Cartilage tissue formation from human adipose-derived stem cells via herbal component (Avocado/soybean unsaponifiables) in scaffold-free culture system.Dental research journalArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAvocado/soybean unsaponifiables such as Arthrocen have been reported to reduce cartilage catabolism and chondrocytic synthesis of inflammatory mediators associated with osteoarthritis (OA). While there is some clinical evidence that avocado/soybean unsaponifiables can reduce OA pain, no preclinical studies have corroborated this observation. The present study determined whether addition of an avocado/soybean unsaponifiable (Arthrocen) to the drinking water of OA rats reduced direct and referred joint pain.
methodsOA was induced in male Wistar rats by intra-articular injection of sodium monoiodoacetate (MIA: 0.3mg) and animals were allowed to recover for 14 days. Arthrocen was added to the drinking water which was available to animals ad libitum. On day 30, joint pain was assessed by dynamic incapacitance while referred pain was determined by von Frey hair algesiometry.
resultsThe joint damage induced by MIA injection was severe and was consistent with end-stage OA. Arthrocen consumption (approximately 35 mg/day) attenuated the joint oedema associated with MIA injection. Hindlimb weight bearing also significantly improved in Arthrocen-treated rats (P<0.05); however, von Frey hair mechanosensitivity was unaffected by this treatment.
conclusionsThese data indicate that Arthrocen has the potential to reduce joint inflammation and pain associated with end-stage OA.
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