ArticlePLoS neglected tropical diseases2018
Prolonging herd immunity to cholera via vaccination: Accounting for human mobility and waning vaccine effects.
Article in PLoS neglected tropical diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Protection from killed whole-cell cholera vaccines: a systematic review and meta-analysis.The Lancet. Global health · 2025Pooled it
- Strategies for achieving a healthy oral cholera vaccine market: Model-enabled scenario exploration of supply and demand dynamics.PLoS neglected tropical diseases · 2026Article
- Quantifying the population-level impact of expanded antibiotic treatment for cholera outbreak management.PLoS computational biology · 2026Article
- Oral Cholera Vaccines as Transmission-Interrupting Tools for Cholera Control: A Narrative Review.Infection and drug resistance · 2026Review
- Cholera surveillance time series in Africa between 2010 and 2023.Gates open research · 2026Article
- Dynamics of IgM and IgA Antibody Response Profile AgainstInternational journal of molecular sciences · 2025Article
- Challenges with achieving and maintaining oral cholera vaccine coverage: insights from serial cross-sectional representative surveys in a cholera-endemic community in the Democratic Republic of the Congo.BMJ public health · 2025Article
- Congruity of genomic and epidemiological data in modelling of local cholera outbreaks.Proceedings. Biological sciences · 2024Article
- Article
- B-Cell Epitope Mapping of theInternational journal of molecular sciences · 2022Article
- Optimizing one-dose and two-dose cholera vaccine allocation in outbreak settings: A modeling study.PLoS neglected tropical diseases · 2022Article
- Assessing the impact of human mobility to predict regional excess death in Ecuador.Scientific reports · 2022Article
- COVID-19 related interdisciplinary methods: Preventing errors and detecting research opportunities.Methods (San Diego, Calif.) · 2021Review
- Licensed and Recommended Inactivated Oral CholeraVaccines: From Development to Innovative Deployment.Tropical medicine and infectious disease · 2021Review
- The use of mobile phone data to inform analysis of COVID-19 pandemic epidemiology.Nature communications · 2020Review
- Vaccine hesitancy and the resurgence of vaccine preventable diseases: the way forward for Malaysia, a Southeast Asian country.Human vaccines & immunotherapeutics · 2020Article
- Comparing alternative cholera vaccination strategies in Maela refugee camp: using a transmission model in public health practice.BMC infectious diseases · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundOral cholera vaccination is an approach to preventing outbreaks in at-risk settings and controlling cholera in endemic settings. However, vaccine-derived herd immunity may be short-lived due to interactions between human mobility and imperfect or waning vaccine efficacy. As the supply and utilization of oral cholera vaccines grows, critical questions related to herd immunity are emerging, including: who should be targeted; when should revaccination be performed; and why have cholera outbreaks occurred in recently vaccinated populations? METHODS AND
findingsWe use mathematical models to simulate routine and mass oral cholera vaccination in populations with varying degrees of migration, transmission intensity, and vaccine coverage. We show that migration and waning vaccine efficacy strongly influence the duration of herd immunity while birth and death rates have relatively minimal impacts. As compared to either periodic mass vaccination or routine vaccination alone, a community could be protected longer by a blended "Mass and Maintain" strategy. We show that vaccination may be best targeted at populations with intermediate degrees of mobility as compared to communities with very high or very low population turnover. Using a case study of an internally displaced person camp in South Sudan which underwent high-coverage mass vaccination in 2014 and 2015, we show that waning vaccine direct effects and high population turnover rendered the camp over 80% susceptible at the time of the cholera outbreak beginning in October 2016.
conclusionsOral cholera vaccines can be powerful tools for quickly protecting a population for a period of time that depends critically on vaccine coverage, vaccine efficacy over time, and the rate of population turnover through human mobility. Due to waning herd immunity, epidemics in vaccinated communities are possible but become less likely through complementary interventions or data-driven revaccination strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.