ArticleNature2018
The landscape of genomic alterations across childhood cancers.
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In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 928 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
928citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
928 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Pooled it
- Influence of genetic biomarkers on cardiac diseases in childhood cancer survivors: a systematic review.The pharmacogenomics journal · 2025Pooled it
- A comparative analysis of hematopoietic stem cell transplantation in pediatric and adult patients: a systematic review and meta-analysis.Frontiers in transplantation · 2025Pooled it
- Genotype-phenotype correlations inOncology reviews · 2025Pooled it
- Targeted therapies plus radiotherapy for diffuse intrinsic pontine glioma: the randomized phase 2 BIOMEDE trial.Nature medicine · 2026Trial
- Frequency and Clinical Significance of Clonal and Subclonal Driver Mutations in High-Risk Neuroblastoma at Diagnosis: A Children's Oncology Group Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025Trial
- Telomere damage enhances immunogenicity of neuroblastoma and accelerates response to anti-PD-L1 treatment.Oncoimmunology · 2026Article
- Rapid Whole Genome Sequencing Enhances Pediatric Cancer Diagnosis.Nature communications · 2026Observational
- The ITCC-P4 PDX Platform Enables Preclinical Testing of Pediatric Cancers.Cancer research · 2026Article
- Epigenetics and In Silico Transcriptome Analysis of Pediatric Acute Myeloid Leukemia.European journal of haematology · 2026Review
- Article
- Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort.Nature communications · 2026Article
- Interdisciplinary management and genetic evaluation of pediatric cancer predisposition syndromes: a retrospective cohort study.European journal of human genetics : EJHG · 2026Article
- Surface and global proteomics identify ROR2 and other proteins as potentially actionable immunotherapeutic targets in osteosarcoma.Cell reports · 2026Article
- Chimeric antigen receptor (CAR)-T cell therapy for solid tumors in pediatric patients: current breakthroughs, dilemmas, and strategies.Experimental hematology & oncology · 2026Review
- Investigation of Epstein-Barr virus or human cytomegalovirus in pediatric gliomas: A retrospective single-center study from Tunisia.Biochemistry and biophysics reports · 2026Article
- Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individuals.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Combined inhibition of CDK4/6 and PI3K pathways exhibit highly synergistic activity and translational potential in Ewing sarcoma.Translational oncology · 2026Article
- Article
- Cellular and Immunotherapy for Pediatric Brain Tumors: A Primer.Current oncology (Toronto, Ont.) · 2026Review
868 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
86 authors.
Susanne N GröbnerHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Barbara C WorstHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Joachim WeischenfeldtEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
Ivo BuchhalterDivision of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kortine KleinheinzDivision of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Vasilisa A RudnevaEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
Pascal D JohannHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Gnana Prakash BalasubramanianHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Maia Segura-WangEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
Sebastian BrabetzHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Sebastian BenderHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Barbara HutterGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Dominik SturmHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Elke PfaffHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Daniel HübschmannDepartment of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Heidelberg, Germany.
Gideon ZipprichDivision of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Michael HeinoldDivision of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jürgen EilsDivision of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Christian LawerenzDivision of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Serap ErkekHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Sander LamboHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Sebastian WaszakEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
Claudia BlattmannGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Arndt BorkhardtGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Michaela KuhlenGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Angelika EggertGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Simone FuldaGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Manfred GesslerTheodor-Boveri-Institute/Biocenter, Developmental Biochemistry, and Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.
Jenny WegertTheodor-Boveri-Institute/Biocenter, Developmental Biochemistry, and Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.
Roland KapplerGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Daniel BaumhoerBone Tumor Reference Center at the Institute of Pathology, University Hospital Basel and University of Basel, Basel, Switzerland.
Stefan BurdachGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Renate Kirschner-SchwabeGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Udo KontnyGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Andreas E KulozikHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Dietmar LohmannGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Simone HettmerDivision of Pediatric Hematology and Oncology, Department of Pediatrics, University Medical Center Freiburg, Freiburg, Germany.
Cornelia EckertGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stefan BielackKlinikum Stuttgart - Olgahospital, Zentrum für Kinder-, Jugend- und Frauenmedizin, Pädiatrie, Stuttgart, Germany.
Michaela NathrathGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Charlotte NiemeyerGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Günther H RichterGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Johannes SchulteGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Reiner SiebertInstitute of Human Genetics, University of Ulm & University Hospital of Ulm, Ulm, Germany.
Frank WestermannGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jan J MolenaarPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Gilles VassalInnovative Therapies for Children with Cancer Consortium and Department of Clinical Research, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Hendrik WittHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
ICGC PedBrain-Seq Project
ICGC MMML-Seq Project
Birgit BurkhardtPediatric Hematology and Oncology, University Hospital Münster, Münster, Germany.
Christian P KratzPediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
Olaf WittHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Cornelis M van TilburgHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Christof M KrammDivision of Pediatric Hematology and Oncology, University Medical Center Göttingen, Göttingen, Germany.
Gudrun FleischhackGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Uta DirksenPediatric Oncology & Hematology, Pediatrics III, University Hospital of Essen, Essen, Germany.
Stefan RutkowskiDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Michael FrühwaldSwabian Children's Cancer Center, Children's Hospital, Klinikum Augsburg, Augsburg, Germany.
Katja von HoffDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stephan WolfGenomics and Proteomics Core Facility, High Throughput Sequencing Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Thomas KlingebielGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ewa KoscielniakKlinikum Stuttgart - Olgahospital, Zentrum für Kinder-, Jugend- und Frauenmedizin, Pädiatrie, Stuttgart, Germany.
Pablo LandgrafUniversity Hospital Cologne, Klinik und Poliklinik für Kinder- und Jugendmedizin, Cologne, Germany.
Jan KosterDepartment of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands.
Adam C ResnickDivision of Neurosurgery, Center for Childhood Cancer Research, Department of Biomedical and Health Informatics and Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Jinghui ZhangDepartment of Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Yanling LiuDepartment of Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Xin ZhouDepartment of Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Angela J WaandersDivision of Oncology, Center for Childhood Cancer Research, Department of Biomedical and Health Informatics and Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, USA.
Danny A ZwijnenburgDepartment of Oncogenomics, Academic Medical Center, Amsterdam, The Netherlands.
Pichai RamanDivision of Neurosurgery, Center for Childhood Cancer Research, Department of Biomedical and Health Informatics and Center for Data-Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Benedikt BrorsGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ursula D WeberGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Paul A NorthcottDivision of Pediatric Neurooncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Kristian W PajtlerHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Marcel KoolHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Rosario M PiroGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jan O KorbelEuropean Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany.
Matthias SchlesnerDivision of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Roland EilsDivision of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
David T W JonesHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Peter LichterGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Lukas ChavezHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Marc ZapatkaDivision of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stefan M PfisterHopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pan-cancer analyses that examine commonalities and differences among various cancer types have emerged as a powerful way to obtain novel insights into cancer biology. Here we present a comprehensive analysis of genetic alterations in a pan-cancer cohort including 961 tumours from children, adolescents, and young adults, comprising 24 distinct molecular types of cancer. Using a standardized workflow, we identified marked differences in terms of mutation frequency and significantly mutated genes in comparison to previously analysed adult cancers. Genetic alterations in 149 putative cancer driver genes separate the tumours into two classes: small mutation and structural/copy-number variant (correlating with germline variants). Structural variants, hyperdiploidy, and chromothripsis are linked to TP53 mutation status and mutational signatures. Our data suggest that 7-8% of the children in this cohort carry an unambiguous predisposing germline variant and that nearly 50% of paediatric neoplasms harbour a potentially druggable event, which is highly relevant for the design of future clinical trials.
Indexed as
GenomicsAdolescentAdultChildChromothripsisCohort StudiesDiploidyDNA Copy Number VariationsGenetic Predisposition to DiseaseGenome, HumanGerm-Line MutationHumansMolecular Targeted TherapyMutationMutation RateNeoplasmsTP53 protein, humanTumor Suppressor Protein p53
Identifiers
PMID
29489754What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.