Evidence map›Paper›PMID 29489705›Full record

ArticleJournal of infusion nursing : the official publication of the Infusion Nurses Society

Antimicrobial Efficacy of a New Chlorhexidine-based Device Against Staphylococcus aureus Colonization of Venous Catheters.

Paulina M Kowalewska, Shawn M Petrik, Attilio E Di Fiore, Alison E Fox-Robichaud

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of infusion nursing : the official publication of the Infusion Nurses Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Paulina M KowalewskaThrombosis and Atherosclerosis Research Institute and Department of Medicine, McMaster University, Hamilton, Ontario, Canada (Dr Fox-Robichaud); Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada (Dr Kowalewska); Comparative Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada (Dr Petrik); and ATTWILL Medical Solutions, Inc, West Jordan, Utah (Mr Di Fiore). Paulina M. Kowalewska, PhD, was an Ontario Centres of Excellence TalentEdge Postdoctoral Fellow at McMaster University during this study and is currently a postdoctoral associate at the University of Western Ontario. Shawn M. Petrik, DVM, MSc, Dip LAM, is the leader of the Comparative Medicine Group at McMaster University, which supports veterinarians, physicians, and scientists who study animal models of human diseases. Attilio E. Di Fiore, BSc, BScEng, PEng, is a biomedical engineer specializing in medical device design and development, with extensive experience in vascular device manufacturing and infection control. Alison E. Fox-Robichaud, MD, MSc, FRCPC, is a clinician scientist and professor of medicine with research interests in inflammation and sepsis. She is also a collaborator on various multicenter knowledge translation studies through the Canadian Critical Care Translational Biology Group and the Canadian Critical Care Trials Group.
Shawn M Petrik
Attilio E Di Fiore
Alison E Fox-Robichaud
Creative Commons · USFox College · USMcMaster University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular catheters are a major cause of nosocomial bloodstream infections. ChloraLock (ATTWILL Medical Solutions, Inc, West Jordan, UT, and ICU Medical, Inc, San Clemente, CA) is a novel antimicrobial device containing chlorhexidine digluconate (CHG) that is fitted onto a syringe and infuses CHG into the catheter lumen during locking. The objective of this study was to evaluate the antimicrobial efficacy of ChloraLock with in vitro tests and its ability to reduce Staphylococcus aureus contamination of catheters in the external jugular veins of Yorkshire swine. ChloraLock significantly reduced the bacterial load in the in vitro tests by up to 6 log10 colony-forming units (CFU) and by 3 to 4 log10 CFU/lumen in vivo in a swine model with 0.9% NaCl catheter locks.

Indexed as

Catheterization, Central VenousEquipment DesignAnimalsAnti-Infective AgentsCatheter-Related InfectionsChlorhexidineDisease Models, AnimalJugular VeinsStaphylococcus aureusSwineAnti-Infective AgentsChlorhexidinechlorhexidine gluconate

Identifiers

PMID29489705
PMCPMC5862007
OpenAlexW2789354209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.