ArticleeLife2018
Opposite regulation of inhibition by adult-born granule cells during implicit versus explicit olfactory learning.
Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- Olfactory neurogenesis plays different parts at successive stages of life, implications for mental health.Frontiers in neural circuits · 2024Review
- Structural spine plasticity: Learning and forgetting of odor-specific subnetworks in the olfactory bulb.PLoS computational biology · 2022Article
- Changes in Dendritic Spine Morphology and Density of Granule Cells in the Olfactory Bulb ofBiology · 2022Article
- Neural processing of the reward value of pleasant odorants.Current biology : CB · 2021Article
- Noradrenergic Activity in the Olfactory Bulb Is a Key Element for the Stability of Olfactory Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Young adult-born neurons improve odor coding by mitral cells.Nature communications · 2020Article
- Context-dependent plasticity of adult-born neurons regulated by cortical feedback.Science advances · 2020Article
- Plasticity in olfactory bulb circuits.Current opinion in neurobiology · 2020Review
- Microglial depletion disrupts normal functional development of adult-born neurons in the olfactory bulb.eLife · 2020Article
- Short-term availability of adult-born neurons for memory encoding.Nature communications · 2019Article
- Microglia Activated by Excess Cortisol Induce HMGB1 Acetylation and Neuroinflammation in the Hippocampal DG Region of Mice Following Cold Exposure.Biomolecules · 2019Article
- The Value of Homework: Exposure to Odors in the Home Cage Enhances Odor-Discrimination Learning in Mice.Chemical senses · 2019Article
- A Spike Time-Dependent Online Learning Algorithm Derived From Biological Olfaction.Frontiers in neuroscience · 2019Article
- Adult Born Periglomerular Cells of Odorant Receptor Specific Glomeruli.Frontiers in neuroanatomy · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both passive exposure and active learning through reinforcement enhance fine sensory discrimination abilities. In the olfactory system, this enhancement is thought to occur partially through the integration of adult-born inhibitory interneurons resulting in a refinement of the representation of overlapping odorants. Here, we identify in mice a novel and unexpected dissociation between passive and active learning at the level of adult-born granule cells. Specifically, while both passive and active learning processes augment neurogenesis, adult-born cells differ in their morphology, functional coupling and thus their impact on olfactory bulb output. Morphological analysis, optogenetic stimulation of adult-born neurons and mitral cell recordings revealed that passive learning induces increased inhibitory action by adult-born neurons, probably resulting in more sparse and thus less overlapping odor representations. Conversely, after active learning inhibitory action is found to be diminished due to reduced connectivity. In this case, strengthened odor response might underlie enhanced discriminability.
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