Trial reportThe Journal of clinical psychiatry
Sluggish Cognitive Tempo as a Possible Predictor of Methylphenidate Response in Children With ADHD: A Randomized Controlled Trial.
Trial report in The Journal of clinical psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01727414 (Medication Response in Children With Predominately Inattentive Type ADHD), which is not on this map. Cited by 25 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Medication Response in Children With Predominately Inattentive Type ADHD
Who cites it
25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Individualized prediction models in ADHD: a systematic review and meta-regression.Molecular psychiatry · 2024Pooled it
- Cognitive disengagement syndrome (sluggish cognitive tempo) and medical conditions: a systematic review and call for future research.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2024Pooled it
- Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD).The Cochrane database of systematic reviews · 2023Pooled it
- Systematic Review: Assessment of Sluggish Cognitive Tempo Over the Past Decade.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Pooled it
- Review
- Cross-Sectional and Quasi-Longitudinal Examination of Childhood and Adult Cognitive Disengagement Syndrome, Depression, Anxiety, Stress, and Insomnia.Journal of clinical medicine · 2025Article
- Neurocognition in children with cognitive disengagement syndrome: accurate but slow.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2024Article
- The prevalence of SCT in China, its comorbidity with ADHD and its association with life events and parental-rearing behaviors.Scientific reports · 2023Article
- Validation of the Farsi Version of the Adult Concentration Inventory for Assessing Cognitive Disengagement Syndrome.Journal of clinical medicine · 2023Article
- Report of a Work Group on Sluggish Cognitive Tempo: Key Research Directions and a Consensus Change in Terminology to Cognitive Disengagement Syndrome.Journal of the American Academy of Child and Adolescent Psychiatry · 2023Article
- Article
- Sluggish Cognitive Tempo among Iranian Children and Adolescents: A Validation Study of the Farsi Child and Adolescent Behavior Inventory (CABI)-Parent Version.Journal of clinical medicine · 2022Article
- Sluggish Cognitive Tempo as a Transdiagnostic Link Between Adult ADHD and Internalizing Symptoms.Journal of psychopathology and behavioral assessment · 2022Article
- "My mom calls it Annaland": A Qualitative Study of Phenomenology, Daily Life Impacts, and Treatment Considerations of Sluggish Cognitive Tempo.Journal of attention disorders · 2022Article
- Sluggish Cognitive Tempo in Pediatric Sickle Cell Disease.Frontiers in neurology · 2022Article
- A Preliminary Evaluation of the Utility of Sluggish Cognitive Tempo Symptoms in Predicting Behavioral Treatment Response in Children with Behavioral Difficulties.Psychological reports · 2021Article
- Pharmacotherapy for Preschool Children with Attention Deficit Hyperactivity Disorder (ADHD): Current Status and Future Directions.CNS drugs · 2021Review
- Atomoxetine might be more effective in improving sluggish cognitive tempo symptoms after switching from methylphenidate: A case report.Clinical case reports · 2021Article
- Excessive Daytime Sleepiness Measurements in Children With Attention Deficit Hyperactivity Disorder.Frontiers in psychiatry · 2020Review
- Clinical correlates of sluggish cognitive tempo in adolescents with autism spectrum disorder.Autism : the international journal of research and practice · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveTo examine whether sluggish cognitive tempo (SCT) symptomatology moderates dose response to methylphenidate and whether the impact of SCT on medication response is distinct from attention-deficit/hyperactivity disorder (ADHD) subtype effects.
methodsStimulant-naive children with ADHD predominantly inattentive type (ADHD-I; n = 126) or ADHD combined type (ADHD-C; n = 45) aged 7-11 years were recruited from the community from September 2006 to June 2013 to participate in a prospective, randomized, double-blind, 4-week crossover trial of long-acting methylphenidate. ADHD diagnosis and subtype were established according to DSM-IV criteria using a structured interview and teacher ADHD symptom ratings. SCT symptoms were assessed using a teacher-rated scale with 2 factors (Sluggish/Sleepy and Daydreamy). Primary outcomes included (1) categorization of children as methylphenidate responders, methylphenidate nonresponders, or placebo responders by 2 blinded physicians and (2) parent and teacher ratings of child behavior on the Vanderbilt ADHD Diagnostic Rating Scales while subjects were on treatment with placebo or 1 of 3 methylphenidate dosages (low, medium, high).
resultsIncreased SCT Sluggish/Sleepy factor scores were associated with being a methylphenidate nonresponder or placebo responder rather than a methylphenidate responder (P = .04). Sluggish/Sleepy factor scores were also linked to diminished methylphenidate dose response for parent- and teacher-rated inattention symptoms (Sluggish/Sleepy factor × dose P = .004). SCT Daydreamy symptoms and ADHD subtype (ADHD-I vs ADHD-C) were not associated with methylphenidate responder status and did not moderate methylphenidate dose response for inattention symptoms.
conclusionsSCT Sluggish/Sleepy symptoms, but not SCT Daydreamy symptoms or ADHD subtype, predicted methylphenidate nonresponse. This novel finding, if replicated, may have important implications for assessing SCT as part of ADHD care.
trial registrationClinicalTrials.gov identifier: NCT01727414.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.