Evidence map›Paper›PMID 29489062›Full record

ArticleStem cells translational medicine2018

Embryonic Stem Cell-Derived Mesenchymal Stem Cells (MSCs) Have a Superior Neuroprotective Capacity Over Fetal MSCs in the Hypoxic-Ischemic Mouse Brain.

Kate E Hawkins, Michelangelo Corcelli, Kate Dowding, Anna M Ranzoni, Filipa Vlahova, Kwan-Leong Hau, Avina Hunjan, Donald Peebles, Pierre Gressens, Henrik Hagberg and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 76 citations in OpenAlex.

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  14. Mesodermal Derivatives of Pluripotent Stem Cells Route to Scarless Healing.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Kate E HawkinsMaternal and Fetal Medicine Department, Institute for Women's Health, University College London, London, United Kingdom.
Michelangelo CorcelliMaternal and Fetal Medicine Department, Institute for Women's Health, University College London, London, United Kingdom.
Kate DowdingMaternal and Fetal Medicine Department, Institute for Women's Health, University College London, London, United Kingdom.
Anna M RanzoniMaternal and Fetal Medicine Department, Institute for Women's Health, University College London, London, United Kingdom.
Filipa VlahovaMaternal and Fetal Medicine Department, Institute for Women's Health, University College London, London, United Kingdom.
Kwan-Leong HauMaternal and Fetal Medicine Department, Institute for Women's Health, University College London, London, United Kingdom.
Avina HunjanMaternal and Fetal Medicine Department, Institute for Women's Health, University College London, London, United Kingdom.
Donald PeeblesMaternal and Fetal Medicine Department, Institute for Women's Health, University College London, London, United Kingdom.
Pierre GressensDepartment of Perinatal Imaging and Health, St. Thomas' Hospital, King's College London, London, United Kingdom.
Henrik HagbergDepartment of Perinatal Imaging and Health, St. Thomas' Hospital, King's College London, London, United Kingdom.
Paolo de CoppiStem Cells and Regenerative Medicine Department, Great Ormond Street Institute for Child Health, University College London, London, United Kingdom.
Mariya HristovaMaternal and Fetal Medicine Department, Institute for Women's Health, University College London, London, United Kingdom.
Pascale V GuillotMaternal and Fetal Medicine Department, Institute for Women's Health, University College London, London, United Kingdom.ORCID 0000-0002-3796-1572
University College London · GBInstitute for Reproductive Health · USKing's College London · GBGreat Ormond Street Hospital · GB

Funding

Department of Health RP_2014-04-046
6 · The paper itself

Abstract

Human mesenchymal stem cells (MSCs) have huge potential for regenerative medicine. In particular, the use of pluripotent stem cell-derived mesenchymal stem cells (PSC-MSCs) overcomes the hurdle of replicative senescence associated with the in vitro expansion of primary cells and has increased therapeutic benefits in comparison to the use of various adult sources of MSCs in a wide range of animal disease models. On the other hand, fetal MSCs exhibit faster growth kinetics and possess longer telomeres and a wider differentiation potential than adult MSCs. Here, for the first time, we compare the therapeutic potential of PSC-MSCs (ES-MSCs from embryonic stem cells) to fetal MSCs (AF-MSCs from the amniotic fluid), demonstrating that ES-MSCs have a superior neuroprotective potential over AF-MSCs in the mouse brain following hypoxia-ischemia. Further, we demonstrate that nuclear factor (NF)-κB-stimulated interleukin (IL)-13 production contributes to an increased in vitro anti-inflammatory potential of ES-MSC-conditioned medium (CM) over AF-MSC-CM, thus suggesting a potential mechanism for this observation. Moreover, we show that induced pluripotent stem cell-derived MSCs (iMSCs) exhibit many similarities to ES-MSCs, including enhanced NF-κB signaling and IL-13 production in comparison to AF-MSCs. Future studies should assess whether iMSCs also exhibit similar neuroprotective potential to ES-MSCs, thus presenting a potential strategy to overcome the ethical issues associated with the use of embryonic stem cells and providing a potential source of cells for autologous use against neonatal hypoxic-ischemic encephalopathy in humans. Stem Cells Translational Medicine 2018;7:439-449.

Indexed as

Amniotic FluidAnimalsBrainCell DifferentiationCells, CulturedCulture Media, ConditionedEmbryonic Stem CellsFemaleFetal Stem CellsHEK293 CellsHumansHypoxiaInduced Pluripotent Stem CellsIschemiaMaleMesenchymal Stem CellsCulture Media, ConditionedCell transplantationEmbryonic stem cellsFetal stem cellsInduced pluripotent stem cellsMesenchymal stem cellsPluripotent stem cells

Identifiers

PMID29489062
PMCPMC5905231
OpenAlexW2789429822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.