ArticleJournal of synchrotron radiation2018
MÖNCH detector enables fast and low-dose free-propagation phase-contrast computed tomography of in situ mouse lungs.
Article in Journal of synchrotron radiation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Investigating the Impact of Sensor Layout on Radiation Hardness in 25 µm Pitch Hybrid Pixel Detectors for 4th Generation Synchrotron Light Sources.Sensors (Basel, Switzerland) · 2025Article
- Quantum Efficiency Measurement and Modeling of Silicon Sensors Optimized for Soft X-ray Detection.Sensors (Basel, Switzerland) · 2024Article
- Simple low dose radiography allows precise lung volume assessment in mice.Scientific reports · 2021Article
- X-ray-Based 3D Virtual Histology-Adding the Next Dimension to Histological Analysis.Molecular imaging and biology · 2018Review
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6 authors.
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Abstract
Due to the complexity of the underlying pathomechanism, in vivo mouse lung-disease models continue to be of great importance in preclinical respiratory research. Longitudinal studies following the cause of a disease or evaluating treatment efficacy are of particular interest but challenging due to the small size of the mouse lung and the fast breathing rate. Synchrotron-based in-line phase-contrast computed tomography imaging has been successfully applied in lung research in various applications, but mostly at dose levels that forbid longitudinal in vivo studies. Here, the novel charge-integrating hybrid detector MÖNCH is presented, which enables imaging of mouse lungs at a pixel size of 25 µm, in less than 10 s and with an entrance dose of about 70 mGy, which therefore will allow longitudinal lung disease studies to be performed in mouse models.
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