ArticleJournal of neurophysiology2018
Pharmacological assessment of the contribution of the arterial baroreflex to sympathetic discharge patterns in healthy humans.
Article in Journal of neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- The role of αAmerican journal of physiology. Heart and circulatory physiology · 2025Article
- Interaction of simultaneous hypoxia and baroreflex loading on control of sympathetic action potential subpopulations.Journal of neurophysiology · 2024Article
- Central αThe Journal of physiology · 2024Article
- A comparison of wavelet-based action potential detection from the NeuroAmp and the Iowa Bioengineering Nerve Traffic Analysis system.Journal of neurophysiology · 2024Article
- Role of the arterial baroreflex in the sympathetic response to hyperinsulinemia in adult humans.American journal of physiology. Endocrinology and metabolism · 2022Article
- Muscle sympathetic single-unit response patterns during progressive muscle metaboreflex activation in young healthy adults.Journal of neurophysiology · 2020Article
- Sympathetic neural recruitment strategies following acute intermittent hypoxia in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology.American journal of physiology. Heart and circulatory physiology · 2020Review
- Effect of varying chemoreflex stress on sympathetic neural recruitment strategies during apnea.Journal of neurophysiology · 2019Article
- The role of the paravertebral ganglia in human sympathetic neural discharge patterns.The Journal of physiology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
To study how changes in baroreceptor afferent activity affect patterns of sympathetic neural activation, we manipulated arterial blood pressure with intravenous nitroprusside (NTP) and phenylephrine (PE) and measured action potential (AP) patterns with wavelet-based methodology. We hypothesized that 1) baroreflex unloading (NTP) would increase firing of low-threshold axons and recruitment of latent axons and 2) baroreflex loading (PE) would decrease firing of low-threshold axons. Heart rate (HR, ECG), arterial blood pressure (BP, brachial catheter), and muscle sympathetic nerve activity (MSNA, microneurography of peroneal nerve) were measured at baseline and during steady-state systemic, intravenous NTP (0.5-1.2 µg·kg
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.