Evidence map›Paper›PMID 29488838›Full record

ArticleJournal of neurophysiology2018

Spatiotemporal evolution of focal epileptiform activity from surface and laminar field recordings in cat neocortex.

Hank Bink, Madineh Sedigh-Sarvestani, Ivan Fernandez-Lamo, Lohith Kini, Hoameng Ung, Duygu Kuzum, Flavia Vitale, Brian Litt, Diego Contreras

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Flexible 3D Kirigami Probes for In Vitro and In Vivo Neural Applications.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hank BinkDepartment of Bioengineering, University of Pennsylvania , Philadelphia, Pennsylvania.
Madineh Sedigh-SarvestaniDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania.
Ivan Fernandez-LamoDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania.
Lohith KiniDepartment of Bioengineering, University of Pennsylvania , Philadelphia, Pennsylvania.
Hoameng UngDepartment of Bioengineering, University of Pennsylvania , Philadelphia, Pennsylvania.
Duygu KuzumDepartment of Electrical and Computer Engineering, University of California San Diego , La Jolla, California.
Flavia VitaleCenter for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, Pennsylvania.
Brian LittDepartment of Bioengineering, University of Pennsylvania , Philadelphia, Pennsylvania.
Diego ContrerasCenter for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, Pennsylvania.

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Geoffrey Karl Aguirre · 1985 to 2026
$19.5M
Training Program in Neuroengineering and MedicineT32NS091006 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Brian Litt · 2015 to 2026
$4.1M
Virtual Resection to Treat EpilepsyR01NS099348 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI BASSETT, DANIELLE SMITH, LITT, BRIAN · 2016 to 2019
$2.3M
Biological 'Living Electrodes' Using Tissue Engineered Axonal Tracts to Probe and Modulate the Nervous SystemU01NS094340 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI CULLEN, DANIEL KACY · 2015 to 2017
$2.0M
NEI NIH HHS P30 EY001583NINDS NIH HHS R01 NS099348NINDS NIH HHS T32 NS091006NINDS NIH HHS U01 NS094340
6 · The paper itself

Abstract

New devices that use targeted electrical stimulation to treat refractory localization-related epilepsy have shown great promise, although it is not well known which targets most effectively prevent the initiation and spread of seizures. To better understand how the brain transitions from healthy to seizing on a local scale, we induced focal epileptiform activity in the visual cortex of five anesthetized cats with local application of the GABA

Indexed as

Cortical ExcitabilityAnimalsCatsDrug Resistant EpilepsyMaleNeocortexepileptic focushigh-resolution ECoGinhibitory surroundrefractory epilepsy

Identifiers

PMID29488838
PMCPMC6032123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.