ArticleMolecular medicine reports2018
Metabolomics analysis reveals an effect of homocysteine on arachidonic acid and linoleic acid metabolism pathway.
Article in Molecular medicine reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- PasteurizedMicroorganisms · 2024Article
- Comparative Metabolome and Transcriptome Analyses Reveal Differential Enrichment of Metabolites with Age inPlants (Basel, Switzerland) · 2024Article
- Article
- Integrative metabolomics science in Alzheimer's disease: Relevance and future perspectives.Ageing research reviews · 2023Review
- Hyperhomocysteinemia-related serum metabolome alterations not normalized by short-term folic acid treatment.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Randomized Trial on the Clinical Utility of a Novel Biomarker Panel to Identify Treatable Determinants of Chronic Pain.Diagnostics (Basel, Switzerland) · 2020Article
- Article
- Effect of Moxibustion on Hyperhomocysteinemia and Oxidative Stress Induced by High-Methionine Diet.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Vascular Protection of TPE-CA on Hyperhomocysteinemia-induced Vascular Endothelial Dysfunction through AA Metabolism Modulated CYPs Pathway.International journal of biological sciences · 2019Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An increase in serum homocysteine level has been associated with an increased risk of vascular disease; however, the biochemical mechanisms that underlie these effects remain largely unknown. The present study aimed to use high-performance liquid chromatography-mass spectrometry (HPLC‑MS) to demonstrate the effects of serum homocysteine on human blood metabolites. A total of 75 fasting serum samples were investigated in the present study. Using a threshold of 15 µmol/l serum homocysteine level, samples were divided into high‑ and low‑homocysteine groups, and the serum extracts were analyzed with an HPLC‑MS‑based method. A total of 269 features exhibited significant differences and correlation with serum homocysteine levels in the electrospray ionization‑positive [ESI(+)] mode, and 69 features were identified in the ESI(‑) mode between the two groups. The principal component analysis plot revealed a separation between the high‑ and the low‑homocysteine groups. Metabolite set enrichment analysis identified arachidonic acid metabolism and linoleic acid metabolism as the two pathways with significantly enriched differences. These results revealed that arachidonic acid and linoleic acid metabolism may be associated with serum homocysteine levels and may be involved in homocysteine-induced vascular disease.
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Registered trials
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