ArticleMicrobial cell (Graz, Austria)2018
Two distinct penicillin binding proteins promote cell division in different
Article in Microbial cell (Graz, Austria), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- Acid-dependent beta-lactam resistance inmBio · 2026Article
- In Vivo Cross-Linking Sheds Light on the Salmonella Divisome in Which PBP3 and PBP3Molecular microbiology · 2024Article
- Evidence of two differentially regulated elongasomes in Salmonella.Communications biology · 2023Article
- Affinity of cefotiam for the alternative penicillin binding protein PBP3SAL used by Salmonella inside host eukaryotic cells.The Journal of antimicrobial chemotherapy · 2023Article
- Conjugation to Enterobactin and Salmochelin S4 Enhances the Antimicrobial Activity and Selectivity of β-Lactam Antibiotics against NontyphoidalACS infectious diseases · 2021Article
- A NovelFrontiers in microbiology · 2021Article
- An alternative penicillin-binding protein involved in Salmonella relapses following ceftriaxone therapy.EBioMedicine · 2020Article
- Mutation of the Carboxy-Terminal Processing Protease inPathogens (Basel, Switzerland) · 2020Article
- Building peptidoglycan inside eukaryotic cells: A view from symbiotic and pathogenic bacteria.Molecular microbiology · 2020Review
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The bacterial cell wall preserves cell integrity in response to external insults and the internal turgor pressure. The major component of the cell wall is the peptidoglycan (PG); a giant macromolecule formed by glycan chains cross-linked by short peptides. The PG is synthesized by a stepwise process that includes cytosolic and periplasmic reactions. The building subunits -muropeptides- are incorporated into the growing macromolecule by transglycolyslation (TG) and transpeptidation (TP) reactions, which constitute the last biosynthetic steps. TP reactions, involving cleavage of the terminal D Ala-D-Ala bond in the stem peptide, are carried out by enzymes known generically as penicillin-binding proteins (PBPs) due to their capacity to bind β lactam antibiotics, which are D Ala-D-Ala structural analogues. On an average, bacterial genomes harbour a minimum of 10 PBP-encoding genes, most of them non-essential. This dispensability has led to the widely accepted concept of functional redundancy for many PBPs. An exemption is the PBP dedicated to build the septal PG required to separate daughter cells during cell division. To date, this division specific PBP was reported as unique in all known bacteria and, as a consequence, "essential". Our recent results obtained in the intracellular bacterial pathogen
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.