ArticleInternational journal for numerical methods in biomedical engineering2018
Effect of KCNQ1 G229D mutation on cardiac pumping efficacy and reentrant dynamics in ventricles: Computational study.
Article in International journal for numerical methods in biomedical engineering, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 9 citations in OpenAlex.
- A multiscale computational model of cardiac electrophysiology for drug-induced pro-arrhythmic risk stratification.Biomedical engineering letters · 2026Article
- An ensemble of parameters from a robust Markov-based model reproduces L-type calcium currents from different human cardiac myocytes.PloS one · 2022Article
- Proarrhythmogenic Effect of the L532P and N588KJournal of Korean medical science · 2020Article
- Computational prediction of the effect of D172N KCNJ2 mutation on ventricular pumping during sinus rhythm and reentry.Medical & biological engineering & computing · 2020Article
- Computational Study to Identify the Effects of the KCNJ2 E299V Mutation in Cardiac Pumping Capacity.Computational and mathematical methods in medicine · 2020Article
- Prediction of Cardiac Mechanical Performance From Electrical Features During Ventricular Tachyarrhythmia Simulation Using Machine Learning Algorithms.Frontiers in physiology · 2020Article
- Effect of myocardial heterogeneity on ventricular electro-mechanical responses: a computational study.Biomedical engineering online · 2019Article
- ERβ Accelerates Diabetic Wound Healing by Ameliorating Hyperglycemia-Induced Persistent Oxidative Stress.Frontiers in endocrinology · 2019Article
- Influence of the KCNQ1 S140G Mutation on Human Ventricular Arrhythmogenesis and Pumping Performance: Simulation Study.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
There is growing interest in genetic arrhythmia since mutations in gene which encodes the ion channel underlie numerous arrhythmias. Hasegawa et al reported that G229D mutation in KCNQ1 underlies atrial fibrillation due to significant shortening of action potential duration (APD) in atrial cells. Here, we predicted whether KCNQ1 G229D mutation affects ventricular fibrillation generation, although it shortens APD slightly compared with the atrial cell. We analyzed the effects of G229D mutation on electrical and mechanical ventricle behaviors (not considered in previous studies). We compared action potential shapes under wild-type and mutant conditions. Electrical wave propagations through ventricles were analyzed during sinus rhythm and reentrant conditions. I
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Registered trials
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