ArticleHuman brain mapping2018
An augmented aging process in brain white matter in HIV.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Application of Diffusion Tensor Imaging (DTI) in the Diagnosis of HIV-Associated Neurocognitive Disorder (HAND): A Meta-Analysis and a System Review.Frontiers in neurology · 2022Pooled it
- Factors associated with brain ageing - a systematic review.BMC neurology · 2021Pooled it
- Fifteen years on: a review of the Cam-CAN study of the cognitive neuroscience of ageing.GeroScience · 2026Review
- The prefrontal cortex, but not the medial temporal lobe, is associated with episodic memory in middle-aged persons with HIV.Journal of the International Neuropsychological Society : JINS · 2024Article
- Implications of vascular depression for successful cognitive aging in HIV Disease.Journal of neurovirology · 2024Article
- Machine learning for predicting cognitive deficits using auditory and demographic factors.PloS one · 2024Article
- The effect of second language acquisition on central auditory processing abilities and its interaction with HIV.Frontiers in language sciences · 2024Article
- Resting state network connectivity alterations in HIV: Parallels with aging.Human brain mapping · 2023Article
- Genetic architecture of brain age and its causal relations with brain and mental disorders.Molecular psychiatry · 2023Article
- Plasma Aβ42/Aβ40 Ratios in Older People With Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Article
- Effects of clinical, comorbid, and social determinants of health on brain ageing in people with and without HIV: a retrospective case-control study.The lancet. HIV · 2023Article
- Artificial Intelligence and Machine Learning Based Prediction of Viral Load and CD4 Status of People Living with HIV (PLWH) on Anti-Retroviral Treatment in Gedeo Zone Public Hospitals.International journal of general medicine · 2023Article
- Machine Learning Quantifies Accelerated White-Matter Aging in Persons With HIV.The Journal of infectious diseases · 2022Article
- HIV-1 Tat reduces apical dendritic spine density throughout the trisynaptic pathway in the hippocampus of male transgenic mice.Neuroscience letters · 2022Article
- The impacts of HIV infection, age, and education on functional brain networks in adults with HIV.Journal of neurovirology · 2022Article
- Cardiometabolic risk factors associated with brain age and accelerate brain ageing.Human brain mapping · 2022Article
- Advanced Brain-Age in Psychotic Psychopathology: Evidence for Transdiagnostic Neurodevelopmental Origins.Frontiers in aging neuroscience · 2022Article
- Associations of alcohol use, HIV infection, and age with brain white matter microstructure.Journal of neurovirology · 2021Article
- Accelerated Brain Aging and Cerebral Blood Flow Reduction in Persons With Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Human immune deficiency virus-related structural alterations in the brain are dependent on age.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveHIV infection and aging are both associated with neurodegeneration. However, whether the aging process alone or other factors associated with advanced age account for the progression of neurodegeneration in the aging HIV-positive (HIV+) population remains unclear.
methodsHIV+ (n = 70) and HIV-negative (HIV-, n = 34) participants underwent diffusion tensor imaging (DTI) and metrics of microstructural properties were extracted from regions of interest (ROIs). A support vector regression model was trained on two independent datasets of healthy adults across the adult life-span (n = 765, Cam-CAN = 588; UiO = 177) to predict participant age from DTI metrics, and applied to the HIV dataset. Predicted brain age gap (BAG) was computed as the difference between predicted age and chronological age, and statistically compared between HIV groups. Regressions assessed the relationship between BAG and HIV severity/medical comorbidities. Finally, correlation analyses tested for associations between BAG and cognitive performance.
resultsBAG was significantly higher in the HIV+ group than the HIV- group F (1, 103) = 12.408, p = .001). HIV RNA viral load was significantly associated with BAG, particularly in older HIV+ individuals (R
conclusionsHIV infection is associated with augmented white matter aging, and greater brain aging is associated with worse cognitive performance in multiple domains.
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Registered trials
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