Evidence map›Paper›PMID 29488263›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2018

High-Density Stretchable Electrode Grids for Chronic Neural Recording.

Klas Tybrandt, Dion Khodagholy, Bernd Dielacher, Flurin Stauffer, Aline F Renz, György Buzsáki, János Vörös

Open access · hybridAbstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 287 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. FromMaterials today. Bio · 2025
    Review
  12. Review
  13. Article
  14. Multifunctional bioelectronics for brain-body circuits.Nature reviews bioengineering · 2025
    Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. A nanowell-based MoSiScience · 2024
    Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Klas TybrandtInstitute for Biomedical Engineering, ETH Zurich, 8092, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-9845-446X
Dion KhodagholyDepartment of Electrical Engineering, Columbia University, New York, NY, 10027, USA.
Bernd DielacherInstitute for Biomedical Engineering, ETH Zurich, 8092, Zurich, Switzerland.
Flurin StaufferInstitute for Biomedical Engineering, ETH Zurich, 8092, Zurich, Switzerland.
Aline F RenzInstitute for Biomedical Engineering, ETH Zurich, 8092, Zurich, Switzerland.
György BuzsákiNYU Neuroscience Institute, School of Medicine, New York University, New York, NY, 10016, USA.
János VörösInstitute for Biomedical Engineering, ETH Zurich, 8092, Zurich, Switzerland.
ETH Zurich · CHNew York University · USLinköping University · SE

Funding

NeuroGrid: a scalable system for large-scale recording of action potentials from the brain surfaceU01NS099705 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BUZSAKI, GYORGY, DEVINSKY, ORRIN · 2016 to 2018
$3.0M
Towards a Complete Description of the Circuitry Underlying Memory replay.U01NS090583 · NINDS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SOLTESZ, IVAN · 2014 to 2016
$2.1M
NINDS NIH HHS U01 NS090583NINDS NIH HHS U01 NS099705
6 · The paper itself

Abstract

Electrical interfacing with neural tissue is key to advancing diagnosis and therapies for neurological disorders, as well as providing detailed information about neural signals. A challenge for creating long-term stable interfaces between electronics and neural tissue is the huge mechanical mismatch between the systems. So far, materials and fabrication processes have restricted the development of soft electrode grids able to combine high performance, long-term stability, and high electrode density, aspects all essential for neural interfacing. Here, this challenge is addressed by developing a soft, high-density, stretchable electrode grid based on an inert, high-performance composite material comprising gold-coated titanium dioxide nanowires embedded in a silicone matrix. The developed grid can resolve high spatiotemporal neural signals from the surface of the cortex in freely moving rats with stable neural recording quality and preserved electrode signal coherence during 3 months of implantation. Due to its flexible and stretchable nature, it is possible to minimize the size of the craniotomy required for placement, further reducing the level of invasiveness. The material and device technology presented herein have potential for a wide range of emerging biomedical applications.

Indexed as

ElectrodesAnimalsNanowiresRatsnanowiresneural electrodesneural interfacessoft electronicsstretchable electronics

Identifiers

PMID29488263
PMCPMC5948103
OpenAlexW2790457354

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.