ArticleEuropean radiology2018
Contrast media injection protocol optimization for dual-energy coronary CT angiography: results from a circulation phantom.
Article in European radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Feasibility of ultra-low flow rate coronary CT angiography using photon-counting detector CT: a prospective randomized trial.European radiology experimental · 2026Trial
- Optimization of hypovascular liver lesion detectability in dual-energy CT using deep learning image reconstruction: a phantom study for potential iodine dose reduction.European radiology experimental · 2026Article
- Contrast media and radiation dose optimization with task-based automatic keV selection: a proof-of-concept study with photon-counting detector CT.European radiology · 2025Article
- Photon-counting versus energy-integrating CT of abdomen-pelvis: a phantom study on the potential for reducing iodine contrast media.European radiology experimental · 2025Article
- Comparing Different Contrast Injection Methods for Multislice Spiral CT Imaging in Triple-Rule-Out Examinations: A Study on Acute Chest Pain Patients.International journal of general medicine · 2025Article
- Gadolinium-based coronary CT angiography on a clinical photon-counting-detector system: a dynamic circulating phantom study.European radiology experimental · 2024Article
- Dual-source photon-counting computed tomography for coronary in-stent observation: influence of heart rate and virtual monoenergetic image.The international journal of cardiovascular imaging · 2024Article
- Critical but commonly neglected factors that affect contrast medium administration in CT.Insights into imaging · 2024Review
- Noise-optimized virtual monoenergetic imaging technology of the third-generation dual-source computed tomography and its clinical applications.Quantitative imaging in medicine and surgery · 2021Review
- Incremental improvement of diagnostic performance of coronary CT angiography for the assessment of coronary stenosis in the presence of calcium using a dual-layer spectral detector CT: validation by invasive coronary angiography.The international journal of cardiovascular imaging · 2021Article
- Optimization of contrast medium volume for abdominal CT in oncologic patients: prospective comparison between fixed and lean body weight-adapted dosing protocols.Insights into imaging · 2021Article
- Dual energy computed tomography virtual monoenergetic imaging: technique and clinical applications.The British journal of radiology · 2019Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the minimum iodine delivery rate (IDR) required to achieve diagnostic coronary attenuation (300 HU) with dual-energy coronary CTA.
methodsAcquisitions were performed on a circulation phantom with a third- generation dual-source CT scanner. Contrast media was injected for a fixed time whilst IDRs varied from 1.0 to 0.3 gI/s in 0.1-gI/s intervals. Noise-optimized virtual monoenergetic imaging (VMI+) reconstructions from 40 to 90 keV in 5 keV increments were generated. Contrast-to-noise ratio (CNR) and coronary HU were measured for each injection.
resultsVMI+ from 40-70 keV reached diagnostic attenuation with at least one IDR. The minimum IDR achieving a diagnostic attenuation ranged from 0.4 gI/s at 40 keV (312.8 HU) to 1.0 gI/s at 70 keV (334.1 HU). Attenuation values reached with IDR of 1.0 gI/s were significantly higher at each keV level (p<0.001). CNR showed a near perfect correlation with the IDR (ρ≥0.962; p<0.001), the IDR of 1.0 gI/s provided the highest CNR at each keV level, achieving the highest overall value at 40 keV (54.0±3.1).
conclusionsIDRs from 0.4-1.0 gI/s associated with VMI+ from 40-70 keV provide diagnostic coronary attenuation with dual-energy coronary CTA. KEY POINTS: • Iodine delivery rate (IDR) is a major determinant of contrast enhancement. • Low-keV noise-optimized monoenergetic images (VMI+) maximize iodine attenuation. • Low-keV VMI+ allows for lower IDRs while maintaining adequate coronary attenuation. • Lowest IDR to reach 300 HU was 0.4 gI/s, 40 keV VMI+.
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