ArticleGeroScience2018
Age modifies the risk factor profiles for acute kidney injury among recently diagnosed type 2 diabetic patients: a population-based study.
Article in GeroScience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Comparative analysis of serious adverse effects of antidiabetic drugs and complications associated with type II diabetes mellitus.BMC pharmacology & toxicology · 2026Observational
- Review
- High versus low chloride load in adult hyperglycemic emergencies with acute kidney injury, a multicenter retrospective cohort study: COMMENT.Internal and emergency medicine · 2024Article
- Article
- Analysis of the clinical features and risk factors of kidney injury in patients with chronic heart failure-a retrospective cohort study.Journal of thoracic disease · 2023Article
- Investigation of the Effects of Stress Hyperglycemia Ratio and Preoperative Computed Tomographic Angiography on the Occurrence of Acute Kidney Injury in Diabetic Patients following Surgical Thromboembolectomy.Tomography (Ann Arbor, Mich.) · 2023Article
- Machine learning for the prediction of acute kidney injury in critical care patients with acute cerebrovascular disease.Renal failure · 2022Article
- Early prediction of COVID-19-associated acute kidney injury: Are serum NGAL and serum Cystatin C levels better than serum creatinine?Clinical biochemistry · 2022Article
- SARS-CoV-2 infection increases risk of acute kidney injury in a bimodal age distribution.BMC nephrology · 2022Observational
- Observational
- Association Between Iron Metabolism and Acute Kidney Injury in Critically Ill Patients With Diabetes.Frontiers in endocrinology · 2022Article
- Incidence, risk factors and outcome of acute kidney injury (AKI) in patients with COVID-19.Clinical and experimental nephrology · 2021Observational
- Cold Saline Perfusion before Ischemia-Reperfusion Is Harmful to the Kidney and Is Associated with the Loss of Ezrin, a Cytoskeletal Protein, in Rats.Biomedicines · 2021Article
- Identification of Potential Gene and MicroRNA Biomarkers of Acute Kidney Injury.BioMed research international · 2021Article
- Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort Study.Frontiers in endocrinology · 2021Article
- Hepatocyte Growth Factor Mimetic ANG-3777 for Cardiac Surgery-Associated Acute Kidney Injury.Kidney international reports · 2020Article
- Article
- Changing relative risk of clinical factors for hospital-acquired acute kidney injury across age groups: a retrospective cohort study.BMC nephrology · 2020Article
- Chronic kidney disease-related osteoporosis is associated with incident frailty among patients with diabetic kidney disease: a propensity score-matched cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- The association of socioeconomic status with incidence and outcomes of acute kidney injury.Clinical kidney journal · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of acute kidney injury (AKI) rises with age and is associated with multiple risk factors. Here, we compared the risk factors for AKI between younger and older incident diabetic patients to examine the trends in risk alteration for individual factors across different age groups. Between 2007 and 2013, we selected all incident type 2 diabetic adults from the Taiwan National Health Insurance registry, stratified based on age: young (< 65 years), old (≥ 65 but < 75 years), and older-old (≥ 75 years). All factors with potential renal influence (e.g., comorbidities, medications, and diagnostics/procedures) were recorded during the study period, with a nested case-controlled approach utilized to identify independent risk factors for AKI in each age group. Totally, 930,709 type 2 diabetic patients were categorized as young (68.7%), old (17.7%), or older-old (13.6%). Older-old patients showed a significantly higher incidence of AKI than the old and the young groups. Cardiovascular morbidities (hypertension, atrial fibrillation, acute coronary syndrome, and cerebrovascular disease) were shown to increase the risk of AKI, although the risk declined with increasing age. Chronic obstructive pulmonary disease and receiving cardiac catheterization elevated the risk of AKI preferentially in the older-old/old and older-old group, respectively, while the administration of angiotensin-converting enzyme/α-blocker and angiotensin receptor blocker/calcium channel blocker reduced the risk of AKI preferentially in the older-old and older-old/old group, respectively. In conclusion, our findings highlight the importance of devising age-specific risk factor panels for AKI in patients with recently diagnosed type 2 diabetes.
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