Evidence map›Paper›PMID 29488007›Full record

ArticleBrain structure & function2018

Tinnitus and temporary hearing loss result in differential noise-induced spatial reorganization of brain activity.

Antonela Muca, Emily Standafer, Aaron K Apawu, Farhan Ahmad, Farhad Ghoddoussi, Mirabela Hali, James Warila, Bruce A Berkowitz, Avril Genene Holt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain structure & function, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Antonela MucaDepartment of Anatomy and Cell Biology, Wayne State University School of Medicine, 550 East Canfield Ave., Detroit, MI, 48201, USA.
Emily StandaferDepartment of Anatomy and Cell Biology, Wayne State University School of Medicine, 550 East Canfield Ave., Detroit, MI, 48201, USA.
Aaron K ApawuDepartment of Anatomy and Cell Biology, Wayne State University School of Medicine, 550 East Canfield Ave., Detroit, MI, 48201, USA.
Farhan AhmadDepartment of Anatomy and Cell Biology, Wayne State University School of Medicine, 550 East Canfield Ave., Detroit, MI, 48201, USA.
Farhad GhoddoussiDepartment of Anesthesiology, Wayne State University School of Medicine, Detroit, MI, USA.
Mirabela HaliDepartment of Anatomy and Cell Biology, Wayne State University School of Medicine, 550 East Canfield Ave., Detroit, MI, 48201, USA.
James WarilaDepartment of Anatomy and Cell Biology, Wayne State University School of Medicine, 550 East Canfield Ave., Detroit, MI, 48201, USA.
Bruce A BerkowitzDepartment of Anatomy and Cell Biology, Wayne State University School of Medicine, 550 East Canfield Ave., Detroit, MI, 48201, USA.
Avril Genene HoltDepartment of Anatomy and Cell Biology, Wayne State University School of Medicine, 550 East Canfield Ave., Detroit, MI, 48201, USA. agholt@med.wayne.edu.
Wayne State University · USJohn D. Dingell VA Medical Center · US

Funding

University of Michigan ERC-supplement (TRT)T42OH008455 · OH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NEITZEL, RICHARD L · 2005 to 2025
$32.3M
Role of calcium channels in the development of diabetic retinopathyR21EY021619 · NEI · WAYNE STATE UNIVERSITY · PI BERKOWITZ, BRUCE A. · 2014 to 2015
$413k
Development of Effective Strategies for Tinnitus Diagnosis and TreatmentI01RX001095 · VA · JOHN D DINGELL VA MEDICAL CENTER · PI HOLT, AVRIL GENENE · 2014 to 2017
–
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention T42 OH008455National Institutes of Health EY021619NEI NIH HHS R21 EY021619NIOSH CDC HHS T42 OH008455Research to Prevent Blindness unrestricted grantRRD VA I01 RX001095U.S. Department of Veterans Affairs 1I01RX001095-01U.S
6 · The paper itself

Abstract

Loud noise frequently results in hyperacusis or hearing loss (i.e., increased or decreased sensitivity to sound). These conditions are often accompanied by tinnitus (ringing in the ears) and changes in spontaneous neuronal activity (SNA). The ability to differentiate the contributions of hyperacusis and hearing loss to neural correlates of tinnitus has yet to be achieved. Towards this purpose, we used a combination of behavior, electrophysiology, and imaging tools to investigate two models of noise-induced tinnitus (either with temporary hearing loss or with permanent hearing loss). Manganese (Mn

Indexed as

Acoustic StimulationAnimalsAuditory ThresholdBrainDisease Models, AnimalEvoked Potentials, Auditory, Brain StemHearing LossHearing TestsMagnetic Resonance ImagingMaleNoiseRatsRats, Sprague-DawleyReflex, StartleTime FactorsTinnitusAcoustic startle reflexGap detectionHearing lossHyperactivityHyperacusisManganese enhanced MRIMEMRINeuronal activityNeuroplasticityPermanent threshold shiftTemporary threshold shiftTinnitus

Identifiers

PMID29488007
PMCPMC6129978
OpenAlexW2792316308

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.