ArticleScience advances2018
Direct single-molecule dynamic detection of chemical reactions.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Real-Time Visualisation of Reaction Kinetics and Dynamics: Single-Molecule Insights into the Iminium-Catalysed Diels-Alder Reaction.Angewandte Chemie (International ed. in English) · 2025Article
- Quantum relaxometry for detecting biomolecular interactions with single NV centers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Full on-device manipulation of olefin metathesis for precise manufacturing.Nature nanotechnology · 2025Article
- Electrical monitoring of single-event protonation dynamics at the solid-liquid interface and its regulation by external mechanical forces.Nature communications · 2024Article
- Technologies for investigating single-molecule chemical reactions.National science review · 2024Review
- Development and mechanisms of photo-induced molecule junction device.Nanophotonics (Berlin, Germany) · 2024Review
- Microscopic theory, analysis, and interpretation of conductance histograms in molecular junctions.Nature communications · 2023Article
- Research on Electric Field-Induced Catalysis Using Single-Molecule Electrical Measurement.Molecules (Basel, Switzerland) · 2023Review
- Review
- Measuring conductance switching in single proteins using quantum tunneling.Science advances · 2022Article
- Stochastic Binding Dynamics of a Photoswitchable Single Supramolecular Complex.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Light-Driven Charge Transport and Optical Sensing in Molecular Junctions.Nanomaterials (Basel, Switzerland) · 2022Review
- Accurate Single-Molecule Indicator of Solvent Effects.JACS Au · 2021Article
- Unveiling the full reaction path of the Suzuki-Miyaura cross-coupling in a single-molecule junction.Nature nanotechnology · 2021Article
- A single-molecule electrical approach for amino acid detection and chirality recognition.Science advances · 2021Article
- Electric field-catalyzed single-molecule Diels-Alder reaction dynamics.Science advances · 2021Article
- Elementary processes of DNA surface hybridization resolved by single-molecule kinetics: implication for macroscopic device performance.Chemical science · 2020Article
- Real-time detection of single-molecule reaction by plasmon-enhanced spectroscopy.Science advances · 2020Article
- Single-molecule and -particle probing crystal edge/corner as highly efficient photocatalytic sites on a single TiOProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Electric field-induced selective catalysis of single-molecule reaction.Science advances · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-molecule detection can reveal time trajectories and reaction pathways of individual intermediates/transition states in chemical reactions and biological processes, which is of fundamental importance to elucidate their intrinsic mechanisms. We present a reliable, label-free single-molecule approach that allows us to directly explore the dynamic process of basic chemical reactions at the single-event level by using stable graphene-molecule single-molecule junctions. These junctions are constructed by covalently connecting a single molecule with a 9-fluorenone center to nanogapped graphene electrodes. For the first time, real-time single-molecule electrical measurements unambiguously show reproducible large-amplitude two-level fluctuations that are highly dependent on solvent environments in a nucleophilic addition reaction of hydroxylamine to a carbonyl group. Both theoretical simulations and ensemble experiments prove that this observation originates from the reversible transition between the reactant and a new intermediate state within a time scale of a few microseconds. These investigations open up a new route that is able to be immediately applied to probe fast single-molecule physics or biophysics with high time resolution, making an important contribution to broad fields beyond reaction chemistry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.