ArticleScience advances2018
Functional odor classification through a medicinal chemistry approach.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- An Integrated Plasmonic Sensing Array for Chemical Fingerprinting and Flavor Profiling in Beverages and Other Liquids.ACS sensors · 2025Article
- Wider Than the Sky: An Alternative to "Mapping" the World Onto the Brain.The European journal of neuroscience · 2025Article
- FlavorMiner: a machine learning platform for extracting molecular flavor profiles from structural data.Journal of cheminformatics · 2024Article
- Mlp4green: A Binary Classification Approach Specifically for Green Odor.International journal of molecular sciences · 2024Article
- Tracing the origin of VOCs in post-consumer plastic film bales.Chemosphere · 2023Article
- Olfactory abstraction: a communicative and metacognitive account.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Predicting odor from molecular structure: a multi-label classification approach.Scientific reports · 2022Article
- Article
- More than meets the AI: The possibilities and limits of machine learning in olfaction.Frontiers in neuroscience · 2022Review
- Workflow to Investigate Subtle Differences in Wine Volatile Metabolome Induced by Different Root Systems and Irrigation Regimes.Molecules (Basel, Switzerland) · 2021Article
- Bitter Taste and Olfactory Receptors: Beyond Chemical Sensing in the Tongue and the Nose.The Journal of membrane biology · 2021Article
- Odor coding in the mammalian olfactory epithelium.Cell and tissue research · 2021Review
- Smell compounds classification using UMAP to increase knowledge of odors and molecular structures linkages.PloS one · 2021Article
- Development of a Korean Culture-Friendly Olfactory Function Test and Optimization of a Diagnostic Cutoff Value.Clinical and experimental otorhinolaryngology · 2020Article
- Exploring the Characteristics of an Aroma-Blending Mixture by Investigating the Network of Shared Odors and the Molecular Features of Their Related Odorants.Molecules (Basel, Switzerland) · 2020Article
- Is It Possible to Predict the Odor of a Molecule on the Basis of its Structure?International journal of molecular sciences · 2019Review
- Design of self-assembly dipeptide hydrogels and machine learning via their chemical features.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- A Critique of Olfactory Objects.Frontiers in psychology · 2019Review
- The Odor Characterizations and Reproductions in Machine Olfactions: A Review.Sensors (Basel, Switzerland) · 2018Review
- Narrative review on artificially intelligent olfaction in halitosis.Journal of oral and maxillofacial pathology : JOMFPReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Crucial for any hypothesis about odor coding is the classification and prediction of sensory qualities in chemical compounds. The relationship between perceptual quality and molecular structure has occupied olfactory scientists throughout the 20th century, but details of the mechanism remain elusive. Odor molecules are typically organic compounds of low molecular weight that may be aliphatic or aromatic, may be saturated or unsaturated, and may have diverse functional polar groups. However, many molecules conforming to these characteristics are odorless. One approach recently used to solve this problem was to apply machine learning strategies to a large set of odors and human classifiers in an attempt to find common and unique chemical features that would predict a chemical's odor. We use an alternative method that relies more on the biological responses of olfactory sensory neurons and then applies the principles of medicinal chemistry, a technique widely used in drug discovery. We demonstrate the effectiveness of this strategy through a classification for esters, an important odorant for the creation of flavor in wine. Our findings indicate that computational approaches that do not account for biological responses will be plagued by both false positives and false negatives and fail to provide meaningful mechanistic data. However, the two approaches used in tandem could resolve many of the paradoxes in odor perception.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.