Evidence map›Paper›PMID 29487871›Full record

Observational studyBioMed research international2018

Serum Soluble Vascular Cell Adhesion Molecule-1 Overexpression Is a Disease Marker in Patients with First-Time Diagnosed Antinuclear Antibodies: A Prospective, Observational Pilot Study.

Mara Oleszowsky, Matthias F Seidel

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mara OleszowskyPraxis für Rheumatologie, Köln, Germany.ORCID 0000-0002-7042-6600
Matthias F SeidelMedizinische Klinik III, Hematology, Oncology and Rheumatology, University Hospital of Bonn, Bonn, Germany.ORCID 0000-0003-1104-9136
Orthopädische Praxis · DEUniversity Hospital Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAntinuclear antibodies (ANA) serve as screening tests for connective tissue diseases but have low specificity. In this pilot study, we aimed to identify patients with first-time positive ANA and musculoskeletal complaints and correlate serum soluble vascular adhesion molecules as biomarkers.

methodsProspective, observational study with 100 ANA-positive patients, comparing them to age- and gender-matched healthy controls (HC,

resultsPatients belonged to three main entities: rheumatoid arthritis (RA,

conclusionOur study suggests that sVCAM-1 is a disease marker independent of standard serum parameters in several rheumatic diseases. This study is registered with EU PAS Register number: EUPAS22154.

Indexed as

Antibodies, AntinuclearArthritis, RheumatoidAutoimmune DiseasesBiomarkersE-SelectinFemaleHumansIntercellular Adhesion Molecule-1MaleMiddle AgedPilot ProjectsProspective StudiesScleroderma, SystemicVascular Cell Adhesion Molecule-1Antibodies, AntinuclearBiomarkersE-SelectinIntercellular Adhesion Molecule-1Vascular Cell Adhesion Molecule-1

Identifiers

PMID29487871
PMCPMC5816882
OpenAlexW2788646282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.