ArticleNeuroImage. Clinical2018
Deficits of entropy modulation in schizophrenia are predicted by functional connectivity strength in the theta band and structural clustering.
Article in NeuroImage. Clinical, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Anomalous self-experiences in biotypes of psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- Influence of recent cannabis use on altered spectral entropy modulation and connectivity strength in patients with psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- Transcranial Magnetic Stimulation-Induced Modulation of Functional Connectivity in Healthy Controls: A TMS-EEG Graph Study.Brain and behavior · 2025Article
- Associations between attenuated auditory p300 event-related potential and cognitive basic symptoms in young people at clinical high risk for psychosis.Psychiatry and clinical neurosciences · 2025Article
- Individualized time windows enhance TMS-EEG signal characterization and improve assessment of cortical function in schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Corollary Discharge Dysfunction as a Possible Substrate of Anomalous Self-experiences in Schizophrenia.Schizophrenia bulletin · 2024Article
- Relation between task-related activity modulation and cortical inhibitory function in schizophrenia and healthy controls: a TMS-EEG study.European archives of psychiatry and clinical neuroscience · 2024Article
- Electroencephalography for the Study of the Auditory P300 Evoked Potential and Derived Measurements.Methods in molecular biology (Clifton, N.J.) · 2023Article
- From temporal to spatial topography: hierarchy of neural dynamics in higher- and lower-order networks shapes their complexity.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- It's in the Timing: Reduced Temporal Precision in Neural Activity of Schizophrenia.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Search for schizophrenia and bipolar biotypes using functional network properties.Brain and behavior · 2021Article
- Overcoming Rest-Task Divide-Abnormal Temporospatial Dynamics and Its Cognition in Schizophrenia.Schizophrenia bulletin · 2021Article
- The Self and Its Prolonged Intrinsic Neural Timescale in Schizophrenia.Schizophrenia bulletin · 2021Article
- Deficits of entropy modulation of the EEG: A biomarker for altered function in schizophrenia and bipolar disorder?Journal of psychiatry & neuroscience : JPN · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spectral entropy (SE) allows comparing task-related modulation of electroencephalogram (EEG) between patients and controls, i.e. spectral changes of the EEG associated to task performance. A SE modulation deficit has been replicated in different schizophrenia samples. To investigate the underpinnings of SE modulation deficits in schizophrenia, we applied graph-theory to EEG recordings during a P300 task and fractional anisotropy (FA) data from diffusion tensor imaging in 48 patients (23 first episodes) and 87 healthy controls. Functional connectivity was assessed from phase-locking values among sensors in the theta band, and structural connectivity was based on FA values for the tracts connecting pairs of regions. From those data, averaged clustering coefficient (CLC), characteristic path-length (PL) and connectivity strength (CS, also known as density) were calculated for both functional and structural networks. The corresponding functional modulation values were calculated as the difference in SE and CLC, PL and CS between the pre-stimulus and response windows during the task. The results revealed a higher functional CS in the pre-stimulus window in patients, predictive of smaller modulation of SE in this group. The amount of increase in theta CS from pre-stimulus to response related to SE modulation in patients and controls. Structural CLC was associated with SE modulation in the patients. SE modulation was predictive of negative symptoms, whereas CLC and PL modulation was associated with cognitive performance in the patients. These results support that a hyperactive functional connectivity and/or structural connective deficits in the patients hamper the dynamical modulation of connectivity underlying cognition.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.