Evidence map›Paper›PMID 29487594›Full record

ArticleFrontiers in immunology2018

Beta-Defensin 2 and 3 Promote Bacterial Clearance of

Yongjian Wu, Dandan Li, Yi Wang, Xi Liu, Yuanqing Zhang, Wenting Qu, Kang Chen, Ngiambudulu M Francisco, Lianqiang Feng, Xi Huang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  3. Post-burn Lung Inflammation Is Associated With Induction of Pulmonary Cathelicidin-related Antimicrobial Peptide and S100a8 in Mice.Journal of burn care & research : official publication of the American Burn Association · 2025
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  4. Investigating the role of the mPGES-PGE₂-EP4 pathway inFrontiers in veterinary science · 2025
    Article
  5. Infectious medicine · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Contribution of Invariant Natural Killer T Cells to the Clearance ofInternational journal of molecular sciences · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. CD103 Promotes the Pro-inflammatory Response of Gastric Resident CD4Frontiers in cellular and infection microbiology · 2020
    Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Yongjian WuProgram of Pathobiology and Immunology, Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Dandan LiProgram of Pathobiology and Immunology, Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Yi WangProgram of Pathobiology and Immunology, Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Xi LiuProgram of Pathobiology and Immunology, Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Yuanqing ZhangSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.
Wenting QuProgram of Pathobiology and Immunology, Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Kang ChenDivision of Clinical Laboratory, Zhongshan Hospital of Sun Yat-sen University, Zhongshan, China.
Ngiambudulu M FranciscoProgram of Pathobiology and Immunology, Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Lianqiang FengProgram of Pathobiology and Immunology, Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Xi HuangProgram of Pathobiology and Immunology, Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Minhao WuProgram of Pathobiology and Immunology, Fifth Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Sun Yat-sen University · CNFifth Affiliated Hospital of Sun Yat-sen University · CNGuangzhou Women and Children Medical Center · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Beta-defensins 2 and 3 (BD2 and BD3) are inducible peptides present at the sites of infection, and they are well characterized for their antimicrobial activities and immune-regulatory functions. However, no study has thoroughly investigated their immunomodulatory effects on macrophage-mediated immune responses against

Indexed as

AnimalsAutophagybeta-DefensinsCell NucleusDown-RegulationEarly Growth Response Protein 1Gene Knockdown TechniquesHumansMacrophagesMiceProto-Oncogene Proteins c-fosPseudomonas aeruginosaPseudomonas InfectionsRAW 264.7 CellsRNA, Small Interferingbeta-defensin 3, mousebeta-DefensinsDEFB103A protein, humanDefb2 protein, mouseDEFB4A protein, humanEarly Growth Response Protein 1EGR1 protein, humanEgr1 protein, mouseFOS protein, humanProto-Oncogene Proteins c-fosRNA, Small Interferingautophagybacterial eradicationbeta-defensinsmacrophagesPseudomonas aeruginosa

Identifiers

PMID29487594
PMCPMC5816924
OpenAlexW2789700413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.