Evidence map›Paper›PMID 29487541›Full record

ArticleFrontiers in physiology2018

Adrenergic Blockade Bi-directionally and Asymmetrically Alters Functional Brain-Heart Communication and Prolongs Electrical Activities of the Brain and Heart during Asphyxic Cardiac Arrest.

Fangyun Tian, Tiecheng Liu, Gang Xu, Duan Li, Talha Ghazi, Trevor Shick, Azeem Sajjad, Michael M Wang, Peter Farrehi, Jimo Borjigin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Surge of neurophysiological coupling and connectivity of gamma oscillations in the dying human brain.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Fangyun TianDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Tiecheng LiuDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Gang XuDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Duan LiDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Talha GhaziDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Trevor ShickDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Azeem SajjadDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Michael M WangDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Peter FarrehiCardiovascular Center, University of Michigan, Ann Arbor, MI, United States.
Jimo BorjiginDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
University of Michigan–Ann Arbor · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sudden cardiac arrest is a leading cause of death in the United States. The neurophysiological mechanism underlying sudden death is not well understood. Previously we have shown that the brain is highly stimulated in dying animals and that asphyxia-induced death could be delayed by blocking the intact brain-heart neuronal connection. These studies suggest that the autonomic nervous system plays an important role in mediating sudden cardiac arrest. In this study, we tested the effectiveness of phentolamine and atenolol, individually or combined, in prolonging functionality of the vital organs in CO

Indexed as

asphyxic cardiac arrestatenololautonomic nervous systemcoherencedirectional connectivityphentolamine

Identifiers

PMID29487541
PMCPMC5816970
OpenAlexW2790170859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.