ArticleScientific reports2018
De novo transcriptome analysis and gene expression profiling of an oleaginous microalga Scenedesmus acutus TISTR8540 during nitrogen deprivation-induced lipid accumulation.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 51 citations in OpenAlex.
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- Regulatory mechanisms of autophagy on DHA and carotenoid accumulation in Crypthecodinium sp. SUN.Biotechnology for biofuels and bioproducts · 2024Article
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- Mechanisms of Sodium-Acetate-Induced DHA Accumulation in a DHA-Producing Microalga,Marine drugs · 2022Article
- Current perspectives on integrated approaches to enhance lipid accumulation in microalgae.3 Biotech · 2021Review
- A multi-omic characterization of temperature stress in a halotolerant Scenedesmus strain for algal biotechnology.Communications biology · 2021Article
- Article
- De novo transcriptome analysis of Chlorella sorokiniana: effect of glucose assimilation, and moderate light intensity.Scientific reports · 2020Article
- Comparative Transcriptome Analysis of Waterlogging-Sensitive and Tolerant Zombi Pea (Plants (Basel, Switzerland) · 2019Article
- Mechanism and enhancement of lipid accumulation in filamentous oleaginous microalgaeBiotechnology for biofuels · 2018Article
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4 authors at 1 institution in 1 country.
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Abstract
Nitrogen deprivation (-N) has been used as a technique to promote lipid accumulation in various microalgae. Scenedesmus acutus is a promising oleaginous green microalga that can be cultivated in organic wastewater for biodiesel production. Nevertheless, the molecular mechanisms controlling S. acutus lipid accumulation in response to -N remain unidentified. Physiological study determined that -N reduced cell growth and photosynthetic pigments. On the other hand, it promoted carbohydrate and neutral lipid accumulation. To find the mechanisms underlying lipid accumulation, we performed de novo transcriptome profiling of the non-model S. acutus in response to -N. The transcriptome analysis revealed that glycolysis and starch degradation were up-regulated; on the contrary, gluconeogenesis, photosynthesis, triacylglycerol (TAG) degradation and starch synthesis were down-regulated by -N. Under -N, the carbon flux was shifted toward fatty acid and TAG synthesis, and the down regulation of TAG lipase genes may contribute to TAG accumulation. A comparative analysis of the -N transcriptomes of oleaginous microalgae identified that the down-regulation of multiple lipase genes was a specific mechanism found only in the -N transcriptome of S. acutus. Our study unraveled the mechanisms controlling -N-induced lipid accumulation in S. acutus, and provided new perspectives for the genetic manipulation of biodiesel-producing microalgae.
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