ArticleNature communications2018
Tailed giant Tupanvirus possesses the most complete translational apparatus of the known virosphere.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 171 papers, 1 of them a synthesis that pooled it.
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Who cites it
171 citing papers in PubMed, 1 synthesis or guideline pooled it, 277 citations in OpenAlex.
- A history of over 40 years of potentially pathogenic free-living amoeba studies in Brazil - a systematic review.Memorias do Instituto Oswaldo Cruz · 2022Pooled it
- Infection cycles of viruses of the phylum Nucleocytoviricota.Nature reviews. Microbiology · 2026Review
- Evidence for the acquisition of a proteorhodopsin-like rhodopsin by a chrysophyte-infecting giant virus.Journal of virology · 2026Article
- Why did some viruses evolve to be giants while others did not?Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A jumbo cyanophage encodes the most complete ribosomal protein set in the known virosphere.bioRxiv : the preprint server for biology · 2026Article
- Widespread genomic islands are hotspots of genome variations and mosaicism in giant viruses.Nature communications · 2026Article
- Refining a giant virus lineage: a novel order unifyingJournal of virology · 2026Article
- tRNA modifications in viral replication.The Journal of biological chemistry · 2026Review
- Elucidating the protein interaction network of one of the largest icosahedral capsids in the virosphere.The EMBO journal · 2026Article
- The selfish ribosome.PLoS biology · 2026Article
- Article
- The selfish ribosome.ArXiv · 2026Article
- A giant virus forms a specialized subcellular environment within its amoeba host for efficient translation.Nature microbiology · 2026Article
- A jumbo cyanophage encodes the most comprehensive ribosomal protein set in the known virosphere.The ISME journal · 2026Article
- Strain-level diversity of giant viruses infecting chlorarachniophyte algae in the subtropical North Pacific.The ISME journal · 2026Article
- A newly isolated giant virus, ushikuvirus, is closely related to clandestinovirus and shows a unique capsid surface structure and host cell interactions.Journal of virology · 2025Article
- The proteomics of the giant cedratvirus particles reveals unique and shared features with pitho-like viruses.Journal of virology · 2025Article
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- Article
- Intracellular iron positively modulates the replicative cycle of mimiviruses, increasing virus production.Journal of virology · 2025Article
111 more citing papers are in PubMed but not listed here.
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Authors and funding
19 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we report the discovery of two Tupanvirus strains, the longest tailed Mimiviridae members isolated in amoebae. Their genomes are 1.44-1.51 Mb linear double-strand DNA coding for 1276-1425 predicted proteins. Tupanviruses share the same ancestors with mimivirus lineages and these giant viruses present the largest translational apparatus within the known virosphere, with up to 70 tRNA, 20 aaRS, 11 factors for all translation steps, and factors related to tRNA/mRNA maturation and ribosome protein modification. Moreover, two sequences with significant similarity to intronic regions of 18 S rRNA genes are encoded by the tupanviruses and highly expressed. In this translation-associated gene set, only the ribosome is lacking. At high multiplicity of infections, tupanvirus is also cytotoxic and causes a severe shutdown of ribosomal RNA and a progressive degradation of the nucleus in host and non-host cells. The analysis of tupanviruses constitutes a new step toward understanding the evolution of giant viruses.
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