ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018
Task Division within the Prefrontal Cortex: Distinct Neuron Populations Selectively Control Different Aspects of Aggressive Behavior via the Hypothalamus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 69 citations in OpenAlex.
- Lateral hypothalamus to dorsal raphe nucleus projections modulate intraspecific attack behavior in male mice.iScience · 2026Article
- A prefrontal cortex-lateral hypothalamus circuit controls stress-driven increased food intake.Nature communications · 2026Article
- Convergence and Segregation of Excitatory and Inhibitory Afferents in the Paraventricular Thalamic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Inhibition of the lateral hypothalamus emboldens adult female spiny mice to huddle with an established group of novel peers.Scientific reports · 2025Article
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- Dynamic changes of serotonin transporter expression in the prefrontal cortex evoked by aggressive social interactions.Neurobiology of stress · 2025Article
- Cingulate to septal circuitry facilitates the preference to affiliate with large peer groups.Current biology : CB · 2024Article
- Mesocorticolimbic circuit mechanisms of social dominance behavior.Experimental & molecular medicine · 2024Review
- Enriched Environment Enhances Sociability Through the Promotion of ESyt1-Related Synaptic Formation in the Medial Prefrontal Cortex.Molecular neurobiology · 2024Article
- The Switchmaze: an open-design device for measuring motivation and drive switching in mice.Peer community journal · 2024Article
- Central amygdala is related to the reduction of aggressive behavior by monosodium glutamate ingestion during the period of development in an ADHD model rat.Frontiers in nutrition · 2024Article
- Hypothalamic volume in pedophilia with or without child sexual offense.European archives of psychiatry and clinical neuroscience · 2023Article
- Post-weaning social isolation in male mice leads to abnormal aggression and disrupted network organization in the prefrontal cortex: Contribution of parvalbumin interneurons with or without perineuronal nets.Neurobiology of stress · 2023Article
- Dissection of insular cortex layer 5 reveals two sublayers with opposing modulatory roles in appetitive drinking behavior.iScience · 2023Article
- Comparing the ontogeny, neurobiology, and function of social play in hamsters and rats.Neuroscience and biobehavioral reviews · 2023Review
- Neurobiology of Aggression-Review of Recent Findings and Relationship with Alcohol and Trauma.Biology · 2023Review
- Article
- Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human.Molecular psychiatry · 2022Article
- Dysregulation of prefrontal parvalbumin interneurons leads to adult aggression induced by social isolation stress during adolescence.Frontiers in molecular neuroscience · 2022Article
- Aggression, Aggression-Related Psychopathologies and Their Models.Frontiers in behavioral neuroscience · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An important question in behavioral neurobiology is how particular neuron populations and pathways mediate the overall roles of brain structures. Here we investigated this issue by studying the medial prefrontal cortex (mPFC), an established locus of inhibitory control of aggression. We established in male rats that dominantly distinct mPFC neuron populations project to and produce dense fiber networks with glutamate release sites in the mediobasal hypothalamus (MBH) and lateral hypothalamus (LH; i.e., two executory centers of species-specific and violent bites, respectively). Optogenetic stimulation of mPFC terminals in MBH distinctively increased bite counts in resident/intruder conflicts, whereas the stimulation of similar terminals in LH specifically resulted in violent bites. No other behaviors were affected by stimulations. These findings show that the mPFC controls aggressiveness by behaviorally dedicated neuron populations and pathways, the roles of which may be opposite to those observed in experiments where the role of the whole mPFC (or of its major parts) has been investigated. Overall, our findings suggest that the mPFC organizes into working units that fulfill specific aspects of its wide-ranging roles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.