ArticleEpidemiology and infection2018
Implications of a school outbreak of multidrug-resistant tuberculosis in Northern China.
Article in Epidemiology and infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 21 citations in OpenAlex.
- Transmissibility and control of tuberculosis in school outbreaks: a modeling study based on four outbreaks in China.BMC infectious diseases · 2024Article
- Epidemiological Characteristics and Spatiotemporal Clustering of Pulmonary Tuberculosis Among Students in Southwest China From 2016 to 2022: Analysis of Population-Based Surveillance Data.JMIR public health and surveillance · 2024Article
- Diagnostic performance of a novel ESAT6-CFP10 skin test for tuberculosis infection in school tuberculosis outbreak in China.Frontiers in public health · 2023Article
- Transmission ofFrontiers in public health · 2023Article
- A university-clustered tuberculosis outbreak during the COVID-19 pandemic in eastern China.Frontiers in public health · 2022Article
- High rate of transmission in a pulmonary tuberculosis outbreak in a junior high school in China, 2020.IJID regions · 2021Article
- Tuberculosis in Adolescents and Young Adults: Emerging Data on TB Transmission and Prevention among Vulnerable Young People.Tropical medicine and infectious disease · 2021Review
- Epidemiological Characteristics of Rifampicin-Resistant Tuberculosis in Students - China, 2015-2019.China CDC weekly · 2021Article
- Tuberculosis Outbreak in an Educational Institution in Henan Province, China.Frontiers in public health · 2021Article
- Isoniazid Preventive Therapy in Contacts of Multidrug-Resistant Tuberculosis.American journal of respiratory and critical care medicine · 2020Article
- Citywide Transmission of Multidrug-resistant Tuberculosis Under China's Rapid Urbanization: A Retrospective Population-based Genomic Spatial Epidemiological Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- An office building outbreak: the changing epidemiology of tuberculosis in Shenzhen, China.Epidemiology and infection · 2020Article
- A tuberculosis school outbreak in China, 2018: reaching an often overlooked adolescent population.Epidemiology and infection · 2019Article
- Adolescent tuberculosis associated with tuberculosis exposure in classrooms and dorm rooms in Guangxi, China.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2019Article
- Tuberculosis Transmission in Households and Classrooms of Adolescent Cases Compared to the Community in China.International journal of environmental research and public health · 2018Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we identified a multidrug-resistant tuberculosis (MDR-TB) outbreak in a high school in northern China. The aim of this work was to describe TB transmission, drug resistance and treatment outcomes for this patient cluster. In January 2017, pulmonary TB was identified in a 17-year-old boy in northern China. Subsequently, a total of 11 TB cases were identified during 6-month follow-up of attendees of the same school. Of five students with latent TB infection (LTBI) receiving isoniazid preventive therapy (IPT), two pulmonary TB cases (40.0%) emerged in March and April, for an active case rate not significantly different from that of the non-IPT group (4/16, 25.0%, P = 0.598). All TB patients were first treated with a standardised first-line treatment regimen administered by the local TB hospital, with 11 of 12 active TB patients exhibiting poor treatment outcomes. Further data demonstrated that all nine patient isolates collected during this outbreak were MDR-TB and shared a common genotypic profile. In conclusion, our data demonstrate that diagnostic delay for the index MDR-TB case of this outbreak played a primary role in transmission of MDR-TB infection within a school setting. Importantly, IPT failed to prevent progression of MDR-TB from LTBI to active TB.
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