Evidence map›Paper›PMID 29486785›Full record

ArticleJournal of translational medicine2018

Identification of candidate genes associated with fibromyalgia susceptibility in southern Spanish women: the al-Ándalus project.

Fernando Estévez-López, Daniel Camiletti-Moirón, Virginia A Aparicio, Víctor Segura-Jiménez, Inmaculada C Álvarez-Gallardo, Alberto Soriano-Maldonado, Milkana Borges-Cosic, Pedro Acosta-Manzano, Rinie Geenen, Manuel Delgado-Fernández and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Fernando Estévez-LópezDepartment of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Carretera de Alfacar, s/n, 18011, Granada, Spain. festevez@ugr.es.ORCID 0000-0003-2960-4142
Daniel Camiletti-MoirónDepartment of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain.ORCID 0000-0002-8856-5967
Virginia A AparicioDepartment of Physiology, Faculty of Pharmacy, Faculty of Sport Sciences and Institute of Nutrition and Food Technology, University of Granada, Granada, Spain.ORCID 0000-0002-2867-378X
Víctor Segura-JiménezDepartment of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain.ORCID 0000-0001-8655-9857
Inmaculada C Álvarez-GallardoDepartment of Physical Education, Faculty of Education Sciences, University of Cádiz, Cádiz, Spain.ORCID 0000-0002-1062-8251
Alberto Soriano-MaldonadoDepartment of Education, Faculty of Education Sciences, University of Almería, Almería, Spain.ORCID 0000-0002-4626-420X
Milkana Borges-CosicDepartment of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Carretera de Alfacar, s/n, 18011, Granada, Spain.ORCID 0000-0002-8276-9387
Pedro Acosta-ManzanoDepartment of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Carretera de Alfacar, s/n, 18011, Granada, Spain.ORCID 0000-0002-4494-2353
Rinie GeenenDepartment of Psychology, Faculty of Social and Behavioural Sciences, Utrecht University, Utrecht, The Netherlands.ORCID 0000-0002-6615-6708
Manuel Delgado-FernándezDepartment of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Carretera de Alfacar, s/n, 18011, Granada, Spain.ORCID 0000-0003-0636-9258
Luis J Martínez-GonzálezLiquid Biopsy and Metastasis Research Group and Genomic Unit, GENyO (Pfizer-University of Granada, Andalusian Government Centre for Genomics and Oncological Research), Granada, Spain.ORCID 0000-0003-2202-0662
Jonatan R RuizPROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.ORCID 0000-0002-7548-7138
María J Álvarez-CuberoLiquid Biopsy and Metastasis Research Group and Genomic Unit, GENyO (Pfizer-University of Granada, Andalusian Government Centre for Genomics and Oncological Research), Granada, Spain.ORCID 0000-0002-5492-9355
Universidad de Granada · ESUniversidad de Cádiz · ESPfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research · ESUniversity of Almería · ESUniversity of Applied Sciences Utrecht · NLUtrecht University · NL

Funding

the Consejería de Turismo, Comercio y Deporte, Junta de Andalucía CTCD-201000019242-TRAthe Spanish Ministry of Economy and Competitiveness BES-2014-067612the Spanish Ministry of Economy and Competitiveness I+D+i DEP2010-15639the Spanish Ministry of Economy and Competitiveness I+D+i DEP2013-40908-R
6 · The paper itself

Abstract

backgroundCandidate-gene studies on fibromyalgia susceptibility often include a small number of single nucleotide polymorphisms (SNPs), which is a limitation. Moreover, there is a paucity of evidence in Europe. Therefore, we compared genotype frequencies of candidate SNPs in a well-characterised sample of Spanish women with fibromyalgia and healthy non-fibromyalgia women.

methodsA total of 314 women with a diagnosis of fibromyalgia (cases) and 112 non-fibromyalgia healthy (controls) women participated in this candidate-gene study. Buccal swabs were collected for DNA extraction. Using TaqMan™ OpenArray™, we analysed 61 SNPs of 33 genes related to fibromyalgia susceptibility, symptoms, or potential mechanisms.

resultsWe observed that the rs841 and rs1799971 GG genotype was more frequently observed in fibromyalgia than in controls (p = 0.04 and p = 0.02, respectively). The rs2097903 AT/TT genotypes were also more often present in the fibromyalgia participants than in their control peers (p = 0.04). There were no differences for the remaining SNPs.

conclusionsWe identified, for the first time, associations of the rs841 (guanosine triphosphate cyclohydrolase 1 gene) and rs2097903 (catechol-O-methyltransferase gene) SNPs with higher risk of fibromyalgia susceptibility. We also confirmed that the rs1799971 SNP (opioid receptor μ1 gene) might confer genetic risk of fibromyalgia. We did not adjust for multiple comparisons, which would be too stringent and yield to non-significant differences in the genotype frequencies between cases and controls. Our findings may be biologically meaningful and informative, and should be further investigated in other populations. Of particular interest is to replicate the present study in a larger independent sample to confirm or refute our findings. On the other hand, by including 61 SNPs of 33 candidate-genes with a strong rationale (they were previously investigated in relation to fibromyalgia susceptibility, symptoms or potential mechanisms), the present research is the most comprehensive candidate-gene study on fibromyalgia susceptibility to date.

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseCase-Control StudiesFemaleFibromyalgiaGene FrequencyHumansLogistic ModelsPolymorphism, Single NucleotideSpainAllelesCaucasianChronic painCOMT geneEpidemiologyGCH1 geneOPRM1 gene

Identifiers

PMID29486785
PMCPMC5828244
OpenAlexW2794633450

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.