ArticleBMC systems biology2018
Nanog induced intermediate state in regulating stem cell differentiation and reprogramming.
Article in BMC systems biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Arsenic Sulfide Induces Apoptosis in Myelodysplastic Neoplasm Cells Through the Suppression of ABI2.Biological procedures online · 2025Article
- Transcriptional regulation as a dose-dependent process: insights from transcription factor tuning.Open biology · 2025Review
- Extreme events in gene regulatory networks with time-delays.Scientific reports · 2025Article
- A novel investigation of NANOG and POU5F1 associations in the pluripotent characterization of ES-like and epiblast cells.Scientific reports · 2024Article
- Morphological and Immunocytochemical Characterization of Paclitaxel-Induced Microcells in Sk-Mel-28 Melanoma Cells.Biomedicines · 2024Article
- Correlation analysis of cancer stem cell marker CD133 and human endogenous retrovirus (HERV)-K env in SKOV3 ovarian cancer cells.Genes & genomics · 2024Article
- Computational analysis of synergism in small networks with different logic.Journal of biological physics · 2023Article
- Network design principle for robust oscillatory behaviors with respect to biological noise.eLife · 2022Article
- Article
- Smurf2-induced degradation of SMAD2 causes inhibition of hair follicle stem cell differentiation.Cell death discovery · 2022Article
- A single-cell resolved cell-cell communication model explains lineage commitment in hematopoiesis.Development (Cambridge, England) · 2021Article
- The anti-apoptotic Bcl-2 protein regulates hair follicle stem cell function.EMBO reports · 2021Article
- Zinc oxide nanoparticles promote the aging process in a size-dependent manner.Journal of materials science. Materials in medicine · 2021Article
- Mathematical modeling of histone modifications reveals the formation mechanism and function of bivalent chromatin.iScience · 2021Article
- FOXC1 Downregulates Nanog Expression by Recruiting HDAC2 to Its Promoter in F9 Cells Treated by Retinoic Acid.International journal of molecular sciences · 2021Article
- D-EE: Distributed software for visualizing intrinsic structure of large-scale single-cell data.GigaScience · 2020Article
- Subpopulations of miniature pig mesenchymal stromal cells with different differentiation potentials differ in the expression of octamer-binding transcription factor 4 and sex determining region Y-box 2.Asian-Australasian journal of animal sciences · 2020Article
- Integrative and perturbation-based analysis of the transcriptional dynamics of TGFβ/BMP system components in transition from embryonic stem cells to neural progenitors.Stem cells (Dayton, Ohio) · 2020Article
- Probing pluripotency gene regulatory networks with quantitative live cell imaging.Computational and structural biotechnology journal · 2020Review
- An enriched network motif family regulates multistep cell fate transitions with restricted reversibility.PLoS computational biology · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundHeterogeneous gene expressions of cells are widely observed in self-renewing pluripotent stem cells, suggesting possible coexistence of multiple cellular states with distinct characteristics. Though the elements regulating cellular states have been identified, the underlying dynamic mechanisms and the significance of such cellular heterogeneity remain elusive.
resultsWe present a gene regulatory network model to investigate the bimodal Nanog distribution in stem cells. Our model reveals a novel role of dynamic conversion between the cellular states of high and low Nanog levels. Model simulations demonstrate that the low-Nanog state benefits cell differentiation through serving as an intermediate state to reduce the barrier of transition. Interestingly, the existence of low-Nanog state dynamically slows down the reprogramming process, and additional Nanog activation is found to be essential to quickly attaining the fully reprogrammed cell state.
conclusionsNanog has been recognized as a critical pluripotency gene in stem cell regulation. Our modeling results quantitatively show a dual role of Nanog during stem cell differentiation and reprogramming, and the importance of the intermediate state during cell state transitions. Our approach offers a general method for analyzing key regulatory factors controlling cell differentiation and reprogramming.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.