Evidence map›Paper›PMID 29486715›Full record

ArticleBMC infectious diseases2018

A nested case-control study of predictors for tuberculosis recurrence in a large UK Centre.

Andrew Rosser, Matthew Richardson, Martin J Wiselka, Robert C Free, Gerrit Woltmann, Galina V Mukamolova, Manish Pareek

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. The impact of the stratification by degree of clinical severity and abandonment risk of tuberculosis treatment.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2021
    Trial
  3. Article
  4. Article
  5. Article
  6. Tobacco dependence treatment for special populations: challenges and opportunities.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2020
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Andrew RosserDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, LE1 7RH, UK.ORCID 0000-0002-7638-5774
Matthew RichardsonDepartment of Infection, Respiratory Biomedical Research Centre, Institute for Lung Health, Immunity and Inflammation, University of Leicester, Leicester, UK.
Martin J WiselkaDepartment of Infection and Tropical Medicine, University Hospitals Leicester NHS Trust, Leicester, UK.
Robert C FreeDepartment of Infection, Respiratory Biomedical Research Centre, Institute for Lung Health, Immunity and Inflammation, University of Leicester, Leicester, UK.
Gerrit WoltmannDepartment of Infection, Respiratory Biomedical Research Centre, Institute for Lung Health, Immunity and Inflammation, University of Leicester, Leicester, UK.
Galina V MukamolovaDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, LE1 7RH, UK.
Manish PareekDepartment of Infection, Immunity and Inflammation, University of Leicester, Leicester, LE1 7RH, UK. mp426@le.ac.uk.
University of Leicester · GBUniversity Hospitals of Leicester NHS Trust · GB

Funding

Biotechnology and Biological Sciences Research Council BB/K000330/1Department of Health PDF-2015-08-102Dowager Countess Eleanor Peel Trust MBE / 12005690.1Public Health Research Programme PDF-2015-08-102
6 · The paper itself

Abstract

backgroundTuberculosis (TB) recurrence represents a challenge to control programs. In low incidence countries, the prevailing risk factors leading to recurrence are poorly characterised.

methodsWe conducted a nested case-control study using the Leicester TB service TBIT database. Cases were identified from database notifications between 1994 and 2014. Controls had one episode and were matched to cases on a ratio of two to one by the date of notification. Multiple imputation was used to account for missing data. Multivariate conditional logistic regression analysis was employed to identify clinical, sociodemographic and TB specific risk factors for recurrence.

resultsFrom a cohort of 4628 patients, 82 TB recurrences occurred (1.8%). Nineteen of 82 patients had paired isolates with MIRU-VNTR strain type profiles available, of which 84% were relapses and 16% reinfections. On multivariate analysis, smoking (OR 3.8; p = 0.04), grade 3/4 adverse drug reactions (OR 5.6; p = 0.02), ethnicity 'Indian subcontinent' (OR 8.5; p = <0.01), ethnicity 'other' (OR 31.2; p = 0.01) and receipt of immunosuppressants (OR 6.8; p = <0.01) were independent predictors of TB recurrence.

conclusionsWithin this UK setting, the rate of TB recurrence was low, predominantly due to relapse. The identification of an elevated recurrence risk amongst the ethnic group contributing most cases to the national TB burden presents an opportunity to improve individual and population health.

Indexed as

AdultCase-Control StudiesCohort StudiesDatabases, FactualFemaleHumansImmunosuppressive AgentsIncidenceMaleMiddle AgedMycobacterium tuberculosisPrognosisRecurrenceRisk FactorsTuberculosisUnited KingdomImmunosuppressive AgentsMycobacterium tuberculosisTBTuberculosisTuberculosis recurrenceTuberculosis reinfectionTuberculosis relapse

Identifiers

PMID29486715
PMCPMC5830048
OpenAlexW2797560918

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.